| 羟乙基芦丁的药理作用 |
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| 引用本文： | 俞平,黎七雄,许静亚,吴玉斌,席汉江,张志善. 羟乙基芦丁的药理作用[J]. 武汉大学学报(医学版), 1982, 0(3) |
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| 作者姓名： | 俞平 黎七雄 许静亚 吴玉斌 席汉江 张志善 |
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| 作者单位： | 湖北医学院药理教研室，湖北医学院药理教研室，湖北医学院药理教研室，湖北医学院药理教研室，湖北医学院药理教研室，湖北医学院药理教研室 |
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| 摘 要： | <正> 人工半合成黄酮化合物——羟乙基芦丁是将芦丁的3′、4′、7位酚羟基上的H以不同数目羟乙基所取代的混合物,从而增加水溶性,降低毒性,并具有新的药理特性。
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THE PHARMACOLOGICAL EFFECTS OF TRIOXYETHYLRUTIN |
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| Abstract: | This article presents the results of a study on the pharmacological effects of Trioxyethylrutin(Paroven). The effects of histamin on the enhancement of capillary permeabitity in mice were antagonized by pretreatment with parven ip 0.5g/kg/day×15 or po 2.5g/kg/day×15. Paroven markedly inhibited the experimental thrombosis in rat and the blood platelet aggregation induced by ADP in vitro.In membrame stabilizing effect on RBC under the action of saponin, the paroven(0.2mg/ml) is better than hydrocortison (0.5mg/ml). These results indicated that parven may be of value to be tried in the treatment of thromb-embolic disease. |
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