| 6,7-二氢-5H-环戊烯并[b]吡啶的合成 |
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| 引用本文： | 葛宜钢,莫卫民,沈振陆,胡宝祥,孙楠.6,7-二氢-5H-环戊烯并[b]吡啶的合成[J].中国医药工业杂志,2006,37(9):586-587. |
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| 作者姓名： | 葛宜钢 莫卫民 沈振陆 胡宝祥 孙楠 |
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| 作者单位： | 浙江工业大学化学工程与材料学院,浙江,杭州,310014 |
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| 摘 要： | 己二酸二乙酯经缩合、氨化、闭环、水解后脱羧、氯化及脱氯等6步反应制得头孢匹罗的中间体6，7-二氢-5H-环戊烯并b]吡啶，总收率31％。
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| 关 键 词： | 6 7-二氢-5H-环戊烯并[b]吡啶 中间体 合成 |
| 文章编号： | 1001-8255（2006）09-0586-02 |
| 收稿时间： | 2005-12-02 |
| 修稿时间： | 2005-12-02 |
Synthesis of 6,7-Dihydro-5H-cyclopenteno [b] pyridine |
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| Authors: | GE Yi-Gang MO Wei-Min SHEN Zhen-Lu HU Bao-Xiang SUN Nan |
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| Institution: | College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014 |
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| Abstract: | 6,7-Dihydro-5H-cyclopenteno b] pyridine, a key intermediate of cefpirome, was synthesized from diethyl adipate by condensation, amination, cyclization, hydrolysis/decarboxylation, chlorination and dechlorination with an overall yield of 31%. |
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| Keywords: | 6 7-dihydro-5H-cyclopenteno Eb] pyridine intermediate synthesis |
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