肝癌组织中ICAM-1的表达和意义

目的研究细胞间黏附分子-1(1CAM-1)在原发性肝癌中的临床意义.方法以免疫组化方法结合全自动图像分析观察40例肝细胞癌组织及其癌旁组织和28例肝硬化组织中ICAM-1的表达.结果40例肝细胞癌组织ICAM-1表达阳性率为80.0%(32/40)、癌旁组织为57.5%(23/40)、肝硬化为53.6%(15/28),阳性率与组织学分类相关.肝癌组织中ICAM-1含量明显高于癌旁及肝硬化组织(P＜0.05),转移组肝癌中ICAM-1的含量明显高于非转移组(P＜0.05),而癌旁及肝硬化组织中表达差异无显著性(P＞0.05).结论肝癌组织中高度表达ICAM-1,ICAM-1有可能作为判断肝硬化及肝癌发展程度及预后的指标之一.

Expression and Significance of ICAM-1 in Hepatocellular Carcinoma

Objective To study the expression and significance of intercellular adhesion molecule_l(ICAM_1) in human hepatocellular carcinoma(HCC).Methods Immumohistochemical staining was performed to detect the the expression of ICAM_1 in tissues of 40 cases of hepatocellular carcinoma, 40 cases of tumor surrounding liver and 28 cases of hepatic cirrhosis.Results The positive rate of ICAM_1 was 80.0%(32/40) for hepatocellular carcinoma,57.5%(23/40) for tumor surrounding liver and 53.6%(15/28) for hepatic cirrhosis respectively. The positive rates were significantly related to the histoligical types. Tissues ICAM_1 in hepatocellular carcinoma was higher in tumor surrounding liver and hepatic cirrhosis (P<0.05), and was also higher in hepatocellular carcinoma with metastasis than those without metastasis (P<0.05), and no significantly related in tumor surrounding liver and hepatic cirrhosis(P>0.05).Conclusion Enhanced ICAM_1 expression was found in hepatocellular carcinoma tissues.ICAM_1 may be a marker of the growth and metastasis of hepatocellular carcinoma.