C-reactive protein |
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Authors: | Alex J. Szalai Alok Agrawal Trevor J. Greenhough John E. Volanakis |
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Affiliation: | 1. Division of Clinical Immunology and Rheumatology, Dept. of Med./Clin. Immunol, University of Alabama at Birmingham, 35294, Birmingham, AL. 2. Department of Physics, Keele University, Staffordshire, Keele, UK
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Abstract: | Over the past few years substantial insight was gained into the biol ogy and biochemistry of human C-reactive protein (CRP). X-ray crystallography in conjunction with mutational analyses, generated the three-dimensional structure of the protein and indicated the topology and structure of ligand-binding sites. Using human CRP transgenic mice infected withStreptococcus pneumoniae, we obtained data that clearly established CRP as an important host defense molecule. Studies using the same mice revealed a previ ously unknown testosterone-dependence of constitutive expression of human CRP. In this article we provide a brief overview of these recent findings. |
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