The CD94/NKG2 C-type lectin receptor complex |
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Authors: | Miguel López-Botet Marta Carretero Juan J. Pérez-Villar Teresa Bellón Manuel Llano Francisco Navarro |
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Affiliation: | 1. Hospital de la Princesa, Universidad Autónoma de Madrid, Spain 2. Servicio de Inmunología Hospital, de la Princesa Diego de León, 62 28006, Madrid, Spain
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Abstract: | A multigene family of human Ig-SF receptors and members of the murine Ly49 C-type lectin family are involved in natural killer (NK) cell-mediated recognition of MHC class I molecules. The human CD94 glycoprotein covalently assembles with different C-type lectins of the NKG2 family. By functional criteria, the CD94/ NKG2-A (kp43) receptor complex appears also involved in NK cell-mediated recognition of different HLA class I allotypes. Similarly to the other NK inhibitory receptors, NKG2-A contains cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). By contrast, NK clones bearing a different receptor complex (CD94/ p39) are triggered upon ligation by CD94-specific monoclonal antibodies (MAbs); the p39 subunit is likely encoded by other member(s) of the NKG2 family. Expression of the different CD94/ NKG2 complexes is warranted to precisely assess their specific interaction with HLA class I molecules, and the molecular basis for their divergent functional properties. |
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