| 氢化阿托酸在大鼠体内时间药代动力学参数的立体选择性 |
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| 引用本文： | 何跃生,路红莉,王殿英,何绍雄.氢化阿托酸在大鼠体内时间药代动力学参数的立体选择性[J].药学学报,1993,28(11):817-822. |
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| 作者姓名： | 何跃生 路红莉 王殿英 何绍雄 |
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| 作者单位： | 天津医药科学研究所，天津医药科学研究所，天津医药科学研究所，天津医药科学研究所 天津 300070，天津 300070，天津 300070，天津 300070 |
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| 基金项目： | 国家自然科学基金,No.3880273 |
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| 摘 要： | 研究了氢化阿托酸在大鼠体内的立体选择药代动力学参数,结果表明,在标准明暗周期下,T1/2α和CL具有立体择性,而反相明暗周期下,有立体选择性的药代动力学参数为T1/2β,AUC,CL,Vc和MRT。比较两种明暗周期各相应参数,除极少数几个参数外,都无显著差异。
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| 关 键 词： | 氢化阿托酸 非甾体抗炎药 立体选择药代动力学参数 |
| 收稿时间： | 1993-02-16 |
THE STEREOSELECTIVITY OF CHRONO-PHARMACOKINETIC PARAMETERS OF HYDRATROPIC ACID IN RATS |
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| YS He,HL Lu,DY Wang and SX He.THE STEREOSELECTIVITY OF CHRONO-PHARMACOKINETIC PARAMETERS OF HYDRATROPIC ACID IN RATS[J].Acta Pharmaceutica Sinica,1993,28(11):817-822. |
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| Authors: | YS He HL Lu DY Wang and SX He |
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| Abstract: | The stereoselective chrono-pharmacokinetic parameters of hydratropic acid in rats were studied. The results showed that under standard light—dark cycle pharmacokinetic parameters of T1/2α and CL are stereoselective and under reverse light—dark cycle, parameters T1/2β, AUC, CL, Vc and MRT were shown to be stereoselective. To compare the corresponding parameters of the two different light—dark cycles using t—test, no differences were found in most of them. |
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| Keywords: | Hydratropic acid Nonsteroidal antiinflammatory drug Stereoselective chronopharmacokinetic parameters |
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