慢性牙周炎伴2型糖尿病患者牙周基础治疗前后牙周状况及血清C反应蛋白水平分析

目的探讨牙周基础治疗对慢性牙周炎伴2型糖尿病患者牙周状况及血清C反应蛋白（C-reactive pro-tein,CRP）水平的影响。方法慢性牙周炎和慢性牙周炎伴2型糖尿病患者各15例,行牙周基础治疗,观察2组治疗前、后探诊出血（bleeding on probing,BOP）、牙周探诊深度（probing depth,PD）、附着丧失（attachment loss,AL）以及血清CRP水平的变化情况。结果慢性牙周炎组治疗后PD减小（1.18±0.52）mm,BOP阳性率减少（29.0±5.0）%,CRP值减小（6.67±4.22）mg/mL,治疗前、后差异均有统计学意义（F=12.03、F=3.41、F=17.38,P〈0.05）。慢性牙周炎伴2型糖尿病组治疗后PD减小（0.57±0.26）mm,BOP阳性率降低（19.0±3.0）%,CRP值减小（3.19±2.33）mg/mL,治疗前、后差异均有统计学意义（F=1.58、F=3.41、F=20.38,P〈0.05）。结论牙周基础治疗可在一定程度上改善慢性牙周炎伴2型糖尿病患者的牙周状况,降低患者血清CRP水平。

Influence of Non-surgical Periodontal Therapy on Serum C-reactive Protein Levels and Periodontal Condition in Patients with Chronic Periodontitis and Type 2 Diabetes Mellitus

Objective To explore the effect of periodontal therapy on serum CRP level in patients with chronic periodontitis and type 2 diabetes mellitus.Methods Clinic index（PD,AL and BOP） and serum CRP level were examined in both chronic periodontitis（CP） group and chronic peiodontitis and type 2 diabetes mellitus（CPDM2）group before and after the periodontal therapy.Results In the CP group,there is a statistically significant difference（P〈0.05） in PD（△PD=1.18±0.52）and BOP（△BOP=29%）,as well as the CPDM2 group experienced a statistically significant difference（P〈0.05） in PD（△PD=0.57±0.26） and BOP（△BOP=19%）.However we could not find an obvious difference in decline degree of CRP between CP group and CPDM2 group（P=0.0825）.Conclusion The periodontal therapy was helpful in improving periodontal status and decreasing the serum CRP level in both CPDM2 group and CP group.