Multiclonal origin of macrolide-resistant Mycoplasma pneumoniae isolates as determined by multilocus variable-number tandem-repeat analysis |
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| Authors: | Liu Yang Ye Xinye Zhang Hong Xu Xiaogang Wang Minggui |
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| Affiliation: | Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China. |
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| Abstract: | There was a high percentage of macrolide resistance in Mycoplasma pneumoniae clinical isolates in China. The genetic relatedness of macrolide-resistant M. pneunomiae strains was investigated using the multilocus variable-number tandem-repeat assay (MLVA). Among 152 M. pneunomiae isolates, the 137 macrolide-resistant strains were clustered into 15 MLVA types, indicating that the high macrolide resistance rate in M. pneumoniae is a result of the dissemination of the multiple resistant clones. |
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