血清和精浆抑制素B在无精子症诊断中的应用研究

目的:评价血清和精浆抑制素B浓度在诊断梗阻性和非梗阻性无精子症中的应用价值。方法:测定25例正常生育者(正常对照组),37例梗阻性无精子症以及33例非梗阻性无精子症者的血清卵泡刺激素(FSH)、血清和精浆抑制素B浓度,对无精子症者行睾丸病理Johnsen评分。结果:精浆和血清抑制素B浓度比值在正常对照组和非梗阻性无精子组分别为2.17和3.63,差异无显著性(P=0.29);在梗阻性无精子症组两者比值为0.18,与正常对照组和非梗阻性无精子症组比较显著降低(P<0.01)。结论:精浆和血清抑制素B浓度比值可用于临床诊断梗阻性和非梗阻性无精子症。

Concentration of Seminal Plasma and Serum Inhibin B: A Predictor in the Diagnosis of Azoospermia

Objective: To evaluate the concentrations of seminal plasma and serum inhibin B in the differential diagnosis of obstructive and non-obstructive azoospermia.Methods: We included 37 infertile men with obstructive azoospermia,another 33 with non-obstructive azoospermia and 25 normal fertile men as controls,and measured the concentrations of their FSH serum,seminal plasma and serum inhibin B,using Testicular Histology Johnson Score for the azoospermia infertile men.Results: The concentration ratio of seminal plasma to serum inhibin B was 2.17 in the control and 3.63 in the non-obstructive azoospermia group,with no significant difference(P=0.29) in between,but obviously lower in the obstructive azoospermia group(0.18),significantly different from the above two(P<0.01).Conclusion: The concentration ratio of seminal plasma to serum inhibin B can be used as a predictor in the diagnosis of obstructive and non-obstructive azoospermia.