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ATP-induced conformational changes in the restriction endonuclease from Escherichia coli K-12. |
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| Authors: | T A Bickle C Brack R Yuan |
| Abstract: | ATP induces a conformational change in the Escherichia coli K-12 restriction enzyme that allows it to discriminate between unmodified and modified DNA recognition sequences. This conformational change does not require ATP hydrolysis. However, ATP hydrolysis is a requirement for DNA cleavage. |
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