庚型肝炎病毒（HGV）感染在原发性肝细胞癌（HCC）发生中作用的探讨

探讨庚型肝炎病毒 (HGV)感染在原发性肝细胞癌 (HCC)发生中的作用。采用RT -PCR法及ELISA法对实验组 (77例HCC患者 ) ,对照 1组 (5 6例健康体检者 )及对照 2组 (38例慢肝肝硬化病人 )分别进行HGVRNA、抗 -HGV和抗 -HCV测定。对随机抽取的实验组 5 8例 ,对照 1组 38例和对照 2组 30例的HGVRNA检测 ,分别查到阳性 3例、2例和 2例。三组间P值均 >0 0 5 ,无显著性差异。三组抗 -HGV检出率分别为 2 5 9%(2 0 / 77) ,7 2 % (4/ 5 6 )和 8 3 % (3/ 36 ) ,实验组与对照 1组P <0 0 1,实验组与对照 2组间P <0 0 5。三组间抗 -HCV检出率分别为 18 1% (14/ 77) ,1 7% (1/ 5 6 )和 2 8% (1/ 36 ) ,2 7例抗 -HGV阳性者中抗 -HCV阳性 12例 ,重叠率 44 4% ,16例抗 -HCV阳性中 11例抗 -HGV阳性 ,重叠率 6 8 7%。结论HGVRNA感染对HCC的发生未见明显作用。抗 -HGV检测难以完全排除抗 -HCV的干扰 ,临床上不应单以抗 -HGV阳性确定HGV感染

The study of the effection on the patients suffered form hepatocellular carcinoma (HCC) by the hepatitis G virus (HGV)infection

To study the effection on the patients suffered from hepatocellular carcinoma (HCC) by the hepatitis G virus (HGV) infection, Serum HGVRNA(NS3), anti-HGV and anti-HCV were detected by RT-PCR or ELISA in experiment group (77patients with HCC), control group1 (56 persons with health checking annual) and control group2 (38 patients with liver cirrhosis after hepatitis ). The Positive rate of HGVRNA was 5 2% (3/58) in experiment group, 5 3%(2/38) in control group1 and 6 7%(2/30) in control group2. P>0 05. The positive rate of anti-HGV and anti-HCV in three groupswere 25 9%(20/77),7 2%(4/56)and 8 3%(3/36),P<0 01;18.1%(14/77),1.7%(1/56)and 2.8%(1/36),P<0.01. The anti-HCV was detected in 12 of 27 patients with anti-HGV positive, the co-positive rate was 44.4%; while the anti-HGV was detected in 11 of 16 patients with anti-HCV positive, the co-positive rate was 68.7%. No effection have been found on the HCC by HGV infection. Anti-HCV may disturb the anti-HGV when the later is being detected by ELISA.