Association of 1,5-anhydroglucitol and 2-h postprandial blood glucose in type 2 diabetic patients

OBJECTIVE—To assess the association of 1,5-anhydroglucitol (1,5-AG) with 2-h postprandial glucose values in type 2 diabetic patients followed over 12 months in an outpatient setting.RESEARCH DESIGN AND METHODS—In 55 patients, we examined self-measured postprandial blood glucose values for correlations with 1,5-AG values over prespecified preceding time periods (3 days, 1 week, and weekly up to 12 weeks).RESULTS—The correlation coefficients for postprandial glucose values were −0.34 (P < 0.05) for 3 days, −0.38 (P < 0.001) for 1 week, and −0.40 (P < 0.001) for 2 weeks preceding the measurement of 1,5-AG. Correlations declined for time periods >2 weeks before measurement of 1,5-AG. The correlation was lower with fasting/preprandial plasma glucose levels. There was no time dependency for the correlation between A1C and fasting or postprandial glucose.CONCLUSIONS—1,5-AG best reflected the 2-h postprandial glucose values of the 2 previous weeks.Recent studies found 1,5-anhydroglucitol (1,5-AG) to generally reflect postprandial hyperglycemia (1–4). However, these studies were cross-sectional, had a comparably short follow-up (1–4), or included patients in the pre-diabetic state (3). The present study assessed the correlation of 2-h postprandial glucose measurements, frequently recommended in clinical practice, with 1,5-AG and aimed at defining the time interval of glucose values yielding the closest correlation with 1,5-AG in diabetic patients.