Role of LKB1 in lung cancer development |
| |
| Authors: | Makowski L Hayes D N |
| |
| Affiliation: | 1Division of Endocrinology, Department of Medicine, Sarah W Stedman Nutrition and Metabolism Center, Duke University Medical Center, Metabolism, and Nutrition, Durham, NC, USA;2Division of Medical Oncology, Department of Internal Medicine, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA |
| |
| Abstract: | Three phenotypically related genetic syndromes and their lesions (LKB1, PTEN, and TSC1/2) are identified as frequently altered in lung cancer. LKB1, a kinase inactivated in 30% of lung cancers, is discussed in this review. Loss of LKB1 regulation often coincident with KRAS activation allows for unchecked growth and the metabolic capacity to accommodate the proliferation. |
| |
| Keywords: | LKB1 STK11 Peutz-Jeghers syndrome review lung cancer heritable tumour syndromes |
| 本文献已被 PubMed 等数据库收录！ |
|
