p53蛋白在鼻腔鼻窦肿瘤组织中的表达

目的初步探讨p53基因突变在鼻腔鼻窦肿瘤发生过程中的作用。方法采用免疫组织化学方法对58例鼻腔鼻窦肿瘤标本进行p53基因产物检测。结果24例内翻性乳头状瘤(IP)中未见阳性p53蛋白;25例恶性肿瘤和9例IP伴鳞状上皮不典型增生中p53蛋白阳性率分别为56%和44.5%,经统计学处理,二组间p53蛋白阳性率无统计学差异,二组对比IP的p53蛋白阳性率有显著性差异(P<0.01);恶性肿瘤中不同性别、吸烟嗜好、癌症发生类型及鳞癌病理分化程度的p53蛋白表达阳性率间差异无显著性(P>0.05)。结论p53基因突变与鼻腔鼻窦恶性肿瘤的发生关系密切,与IP发生可能无关。

Detection of p53 Protein in Tumors of Nasal Cavity and Sinus

Objective To investigate the role of p53 gene mutation in the development of tumors of nasal cavity and sinus. Methods With immunohistochemistry 58 cases of tumor samples of nasal cavity and sinus were detected for the presence of p53 protein. Results There was no positive reaction of p53 in inverted papilloma (IP). The positive rate of p53 protein had significant difference betweem in malignant tumors (56%) and IP with atypical hyperplasia (44.5%)( P <0.01), while the first two groups, difference was not significant ( P >0.05). No significant difference of positive p53 staining was found along the groups of different sex, smoking history, type of malignant tumor, histological differentiation in squamous cell carcinoma(SCC) in 25 cases of the malignant tumor of nasal cavity and sinus( P >0.05). Conclusion The p53 gene mutation has close relation with nasal malignant tumor , and may has no related to the pathogenesis of IP possible.