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Necrobiotic xanthogranuloma successfully treated with autologous stem cell transplantation |
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| Authors: | Jeroen S. Goede Benjamin Misselwitz Christian Taverna Urs Schanz Angela Dispenzieri Yvonne Hummel Ralph M. Trüeb Jörg Fehr |
| Affiliation: | 1. Clinic of Hematology, University Hospital Zürich, R?mistrasse 100, 8091, Zürich, Switzerland 2. Clinic for Internal Medicine, Kantonsspital Münsterlingen, Münsterlingen, Switzerland 3. Division of Hematology, Mayo Clinic, Rochester, USA 4. Clinic for Oncology and Hematology, City Hospital Triemli, Zürich, Switzerland 5. Department of Dermatology, University Hospital Zürich, Zürich, Switzerland |
| Abstract: | Paraproteinemia can be complicated by necrobiotic xanthogranuloma. Therapeutic options for this progressive disease are limited, and there is no agreement on a single best strategy. We report the case of a patient with a massive periorbital infiltration narrowing the palpebral fissure and blinding the patient. Conventional myeloma therapy had only limited benefit in our patient. However, he was successfully treated with high-dose chemotherapy followed by autologous stem cell transplantation, rendering the patient free of symptoms. This is the first report of autologous stem cell transplantation in a patient with necrobiotic xanthogranuloma. |
| Keywords: | Paraprotein Necrobiotic xanthogranuloma Hematopoietic stem cell transplantation Autologous transplantation Blindness |
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