| 非小细胞肺癌中PTEN的表达及临床意义 |
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| 引用本文： | 窦鹏挥. 非小细胞肺癌中PTEN的表达及临床意义[J]. 黑龙江医药科学, 2009, 32(2): 29-30. DOI: 10.3969/j.issn.1008-0104.2009.02.021 |
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| 作者姓名： | 窦鹏挥 |
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| 作者单位： | 佳木斯大学附属第一医院胸心外科,黑龙江,佳木斯,154003 |
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| 摘 要： | 目的：研究PTEN在非小细胞肺癌（NSCLC）中的表达及其临床意义。方法：本研究共取111例石蜡包埋的非小细胞肺癌标本，其中30例含有癌旁组织。采用免疫组化SP法检测PTEN表达情况。结果：肺癌组织中PTEN显著低于癌旁正常组织，差异有显著性。PTEN的表达与肺癌患者的性别、年龄、肿瘤的大小、组织类型及临床分期无关．而与肺癌组织的分化程度、淋巴结转移以及患者的预后密切相关。结论：非小细胞肺癌中存在PTEN蛋白表达的下降。
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| 关 键 词： | 非小细胞肺癌 抑癌基因 PTEN 免疫组织化学 |
PTEN expression in non-small cell lung cancer and its clinical significance |
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| DOU Peng-hui. PTEN expression in non-small cell lung cancer and its clinical significance[J]. Heilongjiang Medicine and Pharmacy, 2009, 32(2): 29-30. DOI: 10.3969/j.issn.1008-0104.2009.02.021 |
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| Authors: | DOU Peng-hui |
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| Affiliation: | The First Affiliated Hospital of Jiamusi University;Jiamusi 154003;China |
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| Abstract: | Objective:To investigate the expression and clinical significance of PTEN in non-small cell lung cancer(NSCLC).Methods:Our study was composed 111 paraffin-embedded NSCLC samples in which 30 had peritumoral tissue.The PTEN expression was examined with SP immunohistochemical techniques.Results:The positive expression rate of PTEN in lung cancer tissue was much more lower than that in the peritumoral tissue,with a significant difference.The expression of PTEN had no correlation with sex,age,tumor size and Hist... |
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| Keywords: | PTEN |
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