| 盐酸川芎嗪静脉注射的药物动力学研究 |
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| 引用本文： | 黄志力,周骋,伍必英,孙瑞元.盐酸川芎嗪静脉注射的药物动力学研究[J].中国药理学通报,1989(4). |
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| 作者姓名： | 黄志力 周骋 伍必英 孙瑞元 |
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| 作者单位： | 皖南医学院定量药理研究室 芜湖241001
(黄志力，周骋，伍必英)，皖南医学院定量药理研究室 芜湖241001(孙瑞元) |
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| 摘 要： | 大鼠按30mg/kg静脉注射盐酸川芎嗪,体内药物动力学呈开放性二室模型。将每组所得数据的均数按Marquardt法迭代拟合,多项指标帮助选择最佳模型。模型分析得其参数为:t_(1/2α)=0.144lh,t_(1/2α)=1.6953h,K_(21)=2.2850h~(-1),K_(10)=0.8605h~(-1),K_(12)=2.0723h~(-1),AUC=83.3660mg·L·h,CL=0.3597L·kg·h~(-1),V_c=0.4182L·kg~(-1),V_(ss)=0.7975L·kg~(-1).分析结果表明:川芎嗪主要分布于血流丰富的大循环和组织,肾脏排泄少,肝脏为主要消除器官。
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| 关 键 词： | 盐酸川芎嗪 药物动力学 房室模型 Marquardt法 |
STUDY ON PHARMACOKINETICS OF TMPH FOR INTRAVENOUS INJECTION IN RAT |
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| Huang Zhili,Zhou Chen,Wu Biying,Sun Ruiyuan.STUDY ON PHARMACOKINETICS OF TMPH FOR INTRAVENOUS INJECTION IN RAT[J].Chinese Pharmacological Bulletin,1989(4). |
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| Authors: | Huang Zhili Zhou Chen Wu Biying Sun Ruiyuan |
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| Abstract: | Pharmacokinetics of Tetramethylpyrazine Hydrochloride (TMPH) in rat was studied by using Ultraviolet Spectrophotometry. After a bolus iv injection of TMPH 30 mg/kg to rat, the pharmacokinetic characteristics are found to fit a two-compartment open model. The Pharmacokinetic parameters are: t 1/2α = 0 .1441h, t 1/2β = l .6953h, K21=2.1850h-1, K10=0.8605h-1, K12= 2 .0723h-1, AUC = 83 .3660mg·L -1h, CL = 0.3599L·kg-1h-1, Yc =0 .4182L·kg-1 , Vss =0 .7975L.kg-1 |
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| Keywords: | Tetramethylpyrazine Hydrochloride Pharmacokin-eties Compartment model Marquardt method |
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