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| 金属硫蛋白在消化管癌组织中的表达及意义 | |
| 引用本文： | 薄爱华,杨邢泽,左瑞峰,齐效勇,赵秀芳,张晓丽. 金属硫蛋白在消化管癌组织中的表达及意义[J]. 中华肿瘤防治杂志, 2004, 11(5): 473-475 |
| 作者姓名： | 薄爱华 杨邢泽 左瑞峰 齐效勇 赵秀芳 张晓丽 |
| 作者单位： | 1. 张家口医学院实验中心,河北,张家口,075029 2. 张家口市第五医院外科,河北,张家口,075000 3. 张北县医院外科,河北,张家口,076450 4. 张家口铁路医院病理科,河北,张家口,075000 |
| 基金项目： | 河北省教育厅重点项目 ( 0 12 761-15 9) |
| 摘 要： | 目的 :观察金属硫蛋白 (metalloth ionein ,MT)耐药标志物在消化管癌中的表达。方法 :采用SP免疫组化方法 ,检测了173例消化管癌中MT的表达状况。结果 :MT在消化管癌中的总阳性率为 5 9 5 4%( 10 3 / 173 )。在食管鳞癌、胃腺癌和大肠癌中的阳性率分别为 75 0 0 % ( 2 4/ 3 2 )、5 0 65 % ( 3 9/ 77)和 62 5 0 % ( 4 0 / 64 )。MT表达率与癌组织分化程度和有否淋巴结转移有显著相关性 ,P <0 0 5。结论 :MT在消化管癌中有较高表达 ,检测肿瘤中MT对制定化疗方案有指导意义 |
| 关 键 词： | 消化系统肿瘤/代谢 金属硫蛋白/生物合成 免疫组织化学 |
| 文章编号： | 1009-4571(2004)05-0473-03 |
| 修稿时间： | 2003-08-05 |
Expression and significance of metallothionein in alimentary canal carcinoma |
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| BO Ai-hua ,YANG Xing-ze ,ZUO Rui-feng ,QI Xiao-yong ,ZHAO Xiu-fang ,ZHANG Xiao-li .Central Laboratory,Zhangjiakou Medical College,Zhangjiakou ,P.R.China. Expression and significance of metallothionein in alimentary canal carcinoma[J]. Chinese Journal of Cancer Prevention and Treatment, 2004, 11(5): 473-475 | |
| Authors: | BO Ai-hua YANG Xing-ze ZUO Rui-feng QI Xiao-yong ZHAO Xiu-fang ZHANG Xiao-li .Central Laboratory Zhangjiakou Medical College Zhangjiakou P.R.China |
| Affiliation: | BO Ai-hua 1,YANG Xing-ze 2,ZUO Rui-feng 3,QI Xiao-yong 1,ZHAO Xiu-fang 4,ZHANG Xiao-li 1 1.Central Laboratory,Zhangjiakou Medical College,Zhangjiakou 075029,P.R.China 2.Department of Surgery,Zhangjiakou Fifth Hospital,Zhangjiakou 075000,P.R.China 3.Department of Surgery,Zhangbei County Hospital,Zhangjiakou 076450,P.R.China 4.Department of Pathology,Zhangjiakou Rail Hospital,Zhangjiakou 075000,P.R.China |
| Abstract: | OBJECTIVE:To study the expression of MT-resistance drug product in alimentary canal cancer. METHODS:The MT of 173 cases of alimentary canal cancer was determined with SP immunohistochemical method.RESULTS:The positive rate of MT was 59.54%(103/173) in alimentary canal cancer.The posivive rates were 75.00%(24/32) and 50.65%(39/77),62.50%(40/64) in esophageal carcinoma,gastral cancer and large intestin cancer,respectively.There was association of MT expression with cancer differentiation degree and lymph nod metastases of the tumors. CONCLUSION:MT expression is quite high in alimentary canal cancer and the MT determined in carcinoma is of significance to direct chemistry scheme. |
| Keywords: | digestive system neoplasms/metabolism metallothionein/biosynthesis immunohistochemistry |
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