| FOXP3和GITR在口腔扁平苔藓及口腔鳞状细胞癌中的表达及意义 |
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| 引用本文： | 漆明,臧磊,刘丽,韩恩善,李国富.FOXP3和GITR在口腔扁平苔藓及口腔鳞状细胞癌中的表达及意义[J].现代口腔医学杂志,2010,24(1):52-55. |
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| 作者姓名： | 漆明 臧磊 刘丽 韩恩善 李国富 |
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| 作者单位： | 1. 宁夏医科大学附属医院口腔科,银川,750004
2. 宁夏医科大学附属医院病理科,银川,750004 |
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| 基金项目： | 宁夏科技厅科技攻关计划，宁夏高等教育研究项目 |
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| 摘 要： | 目的研究FOXP3、GITR在口腔扁平苔藓（OLP）和口腔鳞状细胞癌（OSCC）组织中的表达及其意义。方法采用免疫组化方法检测30例OLP组织、30例OSCC组织和15例口腔正常黏膜（NOM）组织中FOXP3、GITR的表达。结果NOM组FOXP3和GITR阴性表达;OLP组和OSCC组FOXP3和GITR表达分别较NOM组显著增加（P〈0.01）;OLP组和OSCC组之间FOXP3和GITR表达无显著性差异（P〉0.05）;FOXP3和GITR在OLP组和OSCC组中的表达存在正相关关系。结论在OLP的发生及发展成OSCC过程中,FOXP3和GITR均可能起着一定的作用。
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| 关 键 词： | 口腔扁平苔藓 口腔鳞状细胞癌 FOXP3 GITR |
Expression and significance of FOXP3 and GITR in oral lichen planus and oral squamous cell carcinoma |
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| QI Ming,ZANG Lei,LIU Li,et al..Expression and significance of FOXP3 and GITR in oral lichen planus and oral squamous cell carcinoma[J].Journal of Modern Stomatology,2010,24(1):52-55. |
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| Authors: | QI Ming ZANG Lei LIU Li |
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| Institution: | QI Ming,ZANG Lei,LIU Li,et al.Affiliated Hospital of Ningxia Medical University,Yinchuan 750004 |
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| Abstract: | Objective To investigate the expression of FOXP3,GITR in oral lichen planus(OLP) and oral squamous cell carcinoma(OSCC) and its significance.Methods The expression of FOXP3 and GITR in 30 OLP,30 OSCC and 15 normal oral mucosa(NOM) was detected by immunohistochemical methods.Results The expression of FOXP3 and GITR was negative in NOM.The expression of FOXP3 and GITR in both OLP and OSCC was significantly higher than that in NOM(P<0.01).No significant difference of FOXP3 and GITR staining was found between O... |
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| Keywords: | FOXP3 GITR Oral lichen planus (OLP) Oral squamous cell carcinoma(OSCC) FOXP3 GITR |
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