Repeatability of [68Ga]DKFZ11-PSMA PET Scans for Detecting Prostate-specific Membrane Antigen-positive Prostate Cancer |
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| Authors: | Joseph R. Osborne Teja M. Kalidindi Blesida J. Punzalan Kishore Gangangari Daniel E. Spratt Wolfgang A. Weber Steven M. Larson Naga Vara Kishore Pillarsetty |
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| Affiliation: | 1.Department of Radiology,Memorial Sloan Kettering Cancer Center,New York,USA;2.Department of Radiology,Weill Cornell Medical College,New York,USA;3.Molecular Pharmacology Program,Memorial Sloan Kettering Cancer Center,New York,USA;4.Department of Chemistry, Hunter College and PhD Program in Chemistry,The Graduate Center of the City University of New York,New York,USA;5.Department of Radiation Oncology,University of Michigan,Ann Arbor,USA;6.Department of Radiology,Memorial Sloan Kettering Cancer Center, Zuckerman Research Center,New York,USA |
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| Abstract: | PurposeWe studied the effect of varying specific activity of [68Ga]DKFZ-PSMA11 ([68Ga]DP11) on repeated imaging of prostate-specific membrane antigen-positive (PSMA+) xenograft tumors.ProceduresAthymic nude mice bearing PC3-PIP (PSMA+) and PC3 (PSMA?) bilateral flank tumors were assessed to study intra- and inter-day repeatability of [68Ga]DP11 imaging in mice administered [68Ga]DP11 or [67Ga]DP11 (as a dilution tracer) using imaging and biodistribution studies.ResultsRegion of interest (ROI) analysis of the [68Ga]DP11 imaging study indicated that the uptake was constant on the same day or consecutive days. Prior imaging with [68Ga]DP11 did not significantly influence the subsequent uptake of [68Ga]DP11. Uptake of [68Ga]DP11 (60 min) and [67Ga]DP11 (24 h) in PC3-PIP tumors was 12.37 ± 4.19 %ID/g and 12.49 ± 6.88 %ID/g, respectively; [68Ga]DP11 was 13.83 ± 3.77 and 17.76 ± 1.84 on same-day and 15.98 ± 5.82 %ID/g on second-day imaging.ConclusionsThis study demonstrates that [68Ga]DP11, in a given PSMA+ lesion, is constant under several same-day or serial-day imaging conditions. |
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