Absence of human papillomavirus sequences in epithelial breast cancer in a Mexican female population |
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| Authors: | Lisbeth Herrera-Romano Nora Fernández-Tamayo Eduardo Gómez-Conde Juan M Reyes-Cardoso Felipe Ortiz-Gutierrez Guillermo Ceballos Alejandra Valdivia Patricia Pi?a Mauricio Salcedo |
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| Institution: | División de Investigación en Salud, Unidad Médica de Alta Especialidad, Hospital de Especialidades General de División Manuel ávila Camacho, Instituto Mexicano del Seguro Social, Puebla, Mexico. |
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| Abstract: | The role of human papillomavirus (HPV) in breast cancer is controversial. We evaluated 118 breast carcinomas and two paraffin-embedded tissues of lesions of the nipple of Mexican patients for HPV sequences. No carcinoma sample exhibited koilocytosis, in contrast to lesions of the nipple. We subjected purified DNAs to PCR employing two HPV16/E6 or GP5/6 primer set oligonucleotides. Results showed that HPV DNA sequences were absent in the breast tissues. Absence of HPV in breast carcinoma failed to support an association between HPV infection and this carcinoma. |
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