小容量复苏对失血性休克犬血流动力学及内脏组织灌注的影响

目的 探讨小容量复苏对失血性休克犬早期血流动力学及内脏组织灌注的影响.方法分别给予6 ml/kg高渗盐水(HS组)和6 ml/kg高渗盐水加羟乙基淀粉溶液(HSS组)对失血性休克犬进行容量复苏,并以失血量3倍的等渗盐水(NS组)作对照,观察复苏后早期血流动力学及胃肠黏膜组织灌注指标小肠黏膜pH值(pHi)的变化. 结果 (1)3种溶液均能改善失血性休克犬复苏的早期血流动力学及组织灌注,但在30 min后高渗盐水、HSS及等渗盐水容量指标下降,血流动力学下降,其中高渗盐水及等渗盐水下降最为明显.(2)随着血流动力学下降,3组pHi于120 min后开始下降,而动脉乳酸无升高. 结论 (1)小容量高渗盐水在失血性休克模型中的复苏效果与等渗盐水类似,小容量高渗盐水加羟乙基淀粉溶液的效果优于前两组.(2)pHi是监测组织灌注的良好指标,比动脉乳酸更为敏感.

Effects of small volume resuscitation on hemodynamics and visceral perfusion in dog model of hemorrhagic shock

Objective To investigate the effects of small volume resuscitation on hemodynamics and visceral perfusion in dog model of hemorrhagic shock. Methods Twenty-four dogs were hemorrhaged to hold mean arterial blood pressure at 45-55 nun Hg for 45 minutes, and then eight dogs were resuscitated with 6 ml/kg of hypertonic saline (HS group) solution and the other eight resuscitated with 6 ml/kg of hypertonic saline-hydroxyethyl starch (HSS group) solution. The rest eight dogs were set as control and resuscitated with normal saline (NS). Hemodynamics and gastrointestinal intramucosal pH (pHi) were detected after fluid resuscitation. Results (1) All three kinds of solutions could improve early hemodynamics and visceral perfusion. But 30 minutes after fluid resuscitation, the hemodynamics of dogs in HS group, HSS group and NS group began to decrease, with more obvious decrease HS group and NS group compared with HSS group. (2) pHi of three groups began to decrease 120 minutes after fluid resuscitation, but the level of arterial lactate remained unchanged. Conclusions (1) HS has the similar effect as NS in aspect of resuscitation, and HSS is better than HS and NS.(2) pHi is an ideal marker in monitoring the visceral perfusion and has higher sensitivity than arterial lactate.