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Modifications of reduced-size hepatic transplantation in rats
引用本文:杨宁,杨广顺,秦建伟,李齐根. Modifications of reduced-size hepatic transplantation in rats[J]. 中国人民解放军军医大学学报, 2003, 18(4): 235-236
作者姓名:杨宁  杨广顺  秦建伟  李齐根
作者单位:EasternHepatobiliarySurgeryHospital,SecondMilitaryMedicalUniversity,Shanghai200438,China
摘    要:To establish a stable reduced-size hepatic transplantation model in rats. Methods: Liver trans-plantation was performed in accordance with Kamada techniques. Many modifications were made including: Surgical manipulative innovation, adjustment of pre-operative drug administration and removed liver volume. Results: Forty-two rats underwent reduced-size hepatic transplantation; of them 33( 84.6% ) survived more than 1 week. The causes of postoperative death were peritonitis, inferior vena eava thrombns and unknown complications. Condlmion: Manipula-tive innovation and proper drug administration can improve the survival rate of rats apparently. Grafts regeneration canbe triggered by the removal of left lateral segment and caudate lobe.

关 键 词:肝移植 动物模型 鼠 造模方法

Modifications of reduced-size hepatic transplantation in rats
YANG Ning,YANG Guang-shun,QIN Jian-wei,LI Qi-genEastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai ,China. Modifications of reduced-size hepatic transplantation in rats[J]. Journal of Medical Colleges of PLA(China), 2003, 18(4): 235-236
Authors:YANG Ning  YANG Guang-shun  QIN Jian-wei  LI Qi-genEastern Hepatobiliary Surgery Hospital  Second Military Medical University  Shanghai   China
Affiliation:YANG Ning,YANG Guang-shun,QIN Jian-wei,LI Qi-genEastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China
Abstract:Objective: To establish a stable reduced-size hepatic transplantation model in rats. Methods: Liver transplantation was performed in accordance with Kamada techniques. Many modifications were made including: Surgical manipulative innovation, adjustment of pre-operative drug administration and removed liver volume. Results: Forty-two rats underwent reduced-size hepatic transplantation; of them 33(84. 6% ) survived more than 1 week. The causes of postoperative death were peritonitis, inferior vena cava thrombus and unknown complications. Conclusion: Manipulative innovation and proper drug administration can improve the survival rate of rats apparently. Grafts regeneration can be triggered by the removal of left lateral segment and caudate lobe.
Keywords:reduced-size hepatic transplantation  model  rats
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