急性脑血管病患者血浆多种神经肽的含量变化及临床意义

目的:探讨降钙素基因相关肽(CGRP)、神经肽Y(NPY)、内皮素(ET)、神经降压素(NT)、及心房利钠肽(ANP)在脑血管病急性期的作用。方法:应用放射免疫分析法同步测定105例急性脑血管病患者血浆神经肽水平,并与50例健康对照组进行比较。结果:急性脑梗死组,ET、NPY、ANP明显高于对照组(P<0.01),NT、CGRP低于对照组(P<0.05);急性脑出血组ET、NPY、NT含量高于对照组(P<0.01),CGRP、ANP含量明显高于对照组(P<0.001)。结论:神经肽参与了急性脑血管病病理生理过程,其改变可作为早期判断急性脑血管病严重程度指标之一。

The clinical significance and variation of plasma concentration of several neuropeptides in patients with acute cerebrovascular

Objective:To investigate the function and relations of plasma endothelin(ET)、calcitonin gene-related peptide(CGRP)、Neuropeptide Y(NPY)、neurotensin(NT)and atrial natriuretic polypeptide(ANP)in acute cerebrovascular disease.Methods:The concentration of plasma neuropeptides was measured by radioimmunoassay in 105 patients with acute cerebrovascular disease,and compared with the control group.Results:ET、NPY and ANP levels in patients with acute cerebral infarction were significantly higher than the control group(P<0.01),CGRP and NT were lower than the control group(P<0.05);NT、NPY、ET 、CGRP、ANP levels in patients with intracerebral hemorrhage were significantly higher tnan the control group(P<0.01～P<0.001).Conclusion:These neuropeptides play a major role in pathophysiological and pathogenetic mechanisms of acute cerebrovascular disease.The change can be regarded as one factor to decide prognosis of patients in early stage.