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| 用人工膜预测药物经皮吸收的初步研究 | |
| 引用本文： | 姜晓虹, 傅红兴, 金一, 夏目秀视, 森本雍宪. 用人工膜预测药物经皮吸收的初步研究[J]. 中国现代应用药学, 2004, (4): 288-289. |
| 作者姓名： | 姜晓虹, 傅红兴 金一 夏目秀视, 森本雍宪 |
| 作者单位： | 1. 浙江大学药学院,浙江,杭州,310031;杭州师范学院医学院,浙江杭州,310012 2. 浙江大学药学院,浙江,杭州,310031 3. 城西大学药学部,日本,坂户,0295;株式会社TTS技术研究所,日本,坂户,0295 |
| 摘 要： | 目的用BPJ-10高分子材料制备的人工膜评价并预测药物透过皮肤的可行性.方法选取6种模型药物测定药物在BPJ-10高分子材料制备的人工膜上的透过量,并与不同药物在人皮肤上的扩散理论透过曲线进行比较.结果药物在BPJ-10高分子人工膜上的透过速度与人的皮肤上的扩散理论的透过速度相一致.结论本研究中的高分子材料制备的人工膜在一定范围内可替代人皮的药物经皮吸收实验. |
| 关 键 词： | 高分子材料 人工膜 经皮吸收 |
| 文章编号： | 1007-7693(2004)04-0288-02 |
Preliminary study of drug percutaneous absorption using artificial membrane |
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| JIANG Xiao-hong, FU Hong-xing, JIN Yi, Natsume Hideshi, Morimoto Yasumori. Preliminary study of drug percutaneous absorption using artificial membrane[J]. Chinese Journal of Modern Applied Pharmacy, 2004, (4): 288-289. | |
| Authors: | JIANG Xiao-hong FU Hong-xing JIN Yi Natsume Hideshi Morimoto Yasumori |
| Abstract: | OBJECTIVE To predict and evaluation the possibility of skin permeability of drug through the artificial membrane made of BPJ-10 polymer. METHOD Six model drugs were used.Detecting the content of drug through the BPJ-10 polymer membrane,and compare with the different drugs percutaneous absorption profile through human skin.RESULTS The velocity of drugs pass through the BPJ-10 polymer membrane was the same as drugs pass through the huam skin.CONCLUSION The artificial membrane made of such polymer can takes the place of huam skin in percutaneous absorption experiment in some aera. |
| Keywords: | polymer artificial membrane percutaneous absorption |
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