| 高三尖杉酯碱研究进展 |
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| 引用本文： | 杨志欣,王鑫,张蕾,程静,王莹,侯立强. 高三尖杉酯碱研究进展[J]. 现代药物与临床, 2019, 42(4): 781-786 |
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| 作者姓名： | 杨志欣 王鑫 张蕾 程静 王莹 侯立强 |
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| 作者单位： | 黑龙江中医药大学药学院, 黑龙江 哈尔滨 150040;黑龙江中医药大学附属第二医院, 黑龙江 哈尔滨 150001,黑龙江中医药大学药学院, 黑龙江 哈尔滨 150040,黑龙江中医药大学药学院, 黑龙江 哈尔滨 150040,黑龙江中医药大学药学院, 黑龙江 哈尔滨 150040,黑龙江中医药大学药学院, 黑龙江 哈尔滨 150040,黑龙江中医药大学附属第二医院, 黑龙江 哈尔滨 150001 |
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| 基金项目： | 黑龙江省自然科学基金（H2016057,H2017066）;黑龙江中医药大学"优秀创新人才支持计划"项目（2012）;国家教育部春晖计划（Z2008-1-15016）;黑龙江省教育厅骨干教师基金（1251 G058） |
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| 摘 要： | 高三尖杉酯碱存在于三尖杉属植物,2012年被美国FDA批准上市用于慢性粒细胞白血病,引起医药工作者更广泛关注。目前,在其原料药的来源途径、理化性质、抗癌活性、临床应用、作用机制等方面已积累了较大量文献,现有综述主要集中在抗癌机制及在血液病应用方面,对药物研发有重要影响的原料药来源、理化性质、质量控制、构效关系等少有梳理。本文以"homoharringtonine"、"Cephalotaxine"、"Tissue culture"、"SAR"等为中、英文主题词,查询Elsevier及cnki、vip、Wanfang等数据库,归纳整理上述内容,以期为深入开发奠定基础。
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| 关 键 词： | 高三尖杉酯碱 三尖杉属 来源途径 白血病 构效关系 |
| 收稿时间： | 2018-10-18 |
Research progress in homoharringtonine |
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| YANG Zhixin,WANG Xin,ZHANG Lei,CHENG Jing,WANG Ying and HOU Liqiang. Research progress in homoharringtonine[J]. Drugs & Clinic, 2019, 42(4): 781-786 |
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| Authors: | YANG Zhixin WANG Xin ZHANG Lei CHENG Jing WANG Ying HOU Liqiang |
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| Affiliation: | Heilongjiang University of Chinese Medicine-School of Pharmacy, Haerbin 150040, China;The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Haerbin 150001, China,Heilongjiang University of Chinese Medicine-School of Pharmacy, Haerbin 150040, China,Heilongjiang University of Chinese Medicine-School of Pharmacy, Haerbin 150040, China,Heilongjiang University of Chinese Medicine-School of Pharmacy, Haerbin 150040, China,Heilongjiang University of Chinese Medicine-School of Pharmacy, Haerbin 150040, China and The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Haerbin 150001, China |
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| Abstract: | Homoharringtonine exists in the genus Cephalotaxine,approved by FDA for chronic myeloid leukemia in 2012,causing wider concern for pharmaceutical workers.At present,a large number of literatures have been accumulated on the origin of its raw material drugs,physicochemical properties,anticancer activity,clinical application,mechanism of action and so forther.The current review focuses on anticancer mechanisms and applications in hematologic diseases,The origin of raw material drugs,physical and chemical properties,quality control and structure-activity relationship which have important influence on drug research and development are rarely combed.This artical takes "homoharringtonine","Cephalotaxine" "Tissue culture","SAR"as the Chinese and English subject words,queries databases including Elsevier and CNKI,vip,Wanfangand so forther,summarize the above contents,in order to lay the foundation for further development. |
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| Keywords: | homoharringtonine cephalotaxine origine leukimia SAR |
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