| 脉络膜新生血管相关信号通路研究进展 |
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| 引用本文： | 邓宝娣,李嘉,王庭槐. 脉络膜新生血管相关信号通路研究进展[J]. 国际眼科杂志, 2019, 19(5): 762-765 |
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| 作者姓名： | 邓宝娣 李嘉 王庭槐 |
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| 作者单位： | 中国广东省广州市,中山大学中山医学院生理学教研室; 中国广东省广州市,中山大学中山眼科中心 眼科学国家重点实验室,中国广东省广州市,中山大学中山眼科中心 眼科学国家重点实验室,中国广东省广州市,中山大学中山医学院生理学教研室 |
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| 基金项目： | 国家自然科学基金资助项目(No.81572585,81670873) |
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| 摘 要： | 脉络膜新生血管(CNV)又称视网膜下新生血管，是多种眼底病的基础病理改变，也是导致黄斑区病理性损害和严重视功能障碍的常见原因。目前CNV的治疗研究多以血管内皮生长因子(VEGF)信号通路为靶向治疗，但其存在疗效不持久、需重复注射以及眼内注射可能带来的副作用等问题。因此，进一步研究CNV发生发展进程中可能具有重要影响作用的信号通路，对研发治疗CNV的新药物和新技术具有十分重要的作用。本文综述目前已报道的CNV相关信号通路的研究进展，以期深入了解CNV的发生发展进程，并为相关疾病的诊疗提供新思路。
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| 关 键 词： | 脉络膜新生血管 VEGF信号通路 Wnt信号通路 Shh信号通路 TGF-β/Smad信号通路 Notch信号通路 |
| 收稿时间： | 2018-11-02 |
| 修稿时间： | 2019-04-02 |
Recent advances in signaling pathways related to choroidal neovascularization |
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| Bao-Di Deng,Jia Li and Ting-Huai Wang. Recent advances in signaling pathways related to choroidal neovascularization[J]. International Eye Science, 2019, 19(5): 762-765 |
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| Authors: | Bao-Di Deng Jia Li Ting-Huai Wang |
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| Affiliation: | Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510275, Guangdong Province, China; Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China,Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China and Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510275, Guangdong Province, China |
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| Abstract: | Choroid neovascularization is the characteristic pathological change of many fundus diseases and is the most common cause for severe vision loss and metamorphopsia. Among the pathogenic factors, VEGF is considered to be the most important and treatment targeting VEGF showed promising results. However, anti-VEGF agents need to be administrated frequently and they are usually expensive. Also, some patients got no response to this treatment. These facts force us to find other pathway that involves in the formation of CNV. This article reviews the latest research on CNV-related signaling pathways so as to provide a deeper look into CNV and hopefully point out new directions for treating diseases that share similar pathogenesis. |
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