HCV与HBV共感染影响血清HBV核酸与表面抗原水平

分析和评估HCV与HBV共感染对HBV临床指征的影响。采集152例有静脉吸毒史HBV感染者血浆,其中HBV/HCV共感染组52例,HBV单感染组100例。检测分析包括ALT和AST、HBV表面抗原(HBsAg)、e抗原、e抗体、HBV DNA及anti-HCV IgG与HCV RNA。结果显示,两组样本的ALT和AST水平无显著差异(P=0.097, P=0.184)；HBV/HCV共感染组HBsAg水平显著低于HBV单感染组HBsAg水平(P=0.020)；共感染组HBV DNA阳性率显著低于HBV单感染组HBV DNA阳性率(P=0.004),且共感染组中HBV DNA载量也显著低于HBV单感染组HBV DNA载量(P=0.031)。进一步分析发现:在HBV单感染患者中的HBV DNA和HBsAg具有良好的正相关关系(r=0.752, P<0.001),但在HBV/HCV共感染患者中相关性减弱(r=0.387, P=0.042)。本研究显示HCV共感染可能与HBV存在竞争关系,从而影响HBV病毒复制水平及表面抗原分泌。

HCV coinfection with HBV impact the level of nucleic acid and HBsAg of HBV in serum

To analyze and evaluate the effect of HCV coinfection on clinical indicators of HBV-infected patients. 152 individuals with HBV infection from intravenous drug users were enrolled. 52 individuals were HBV/HCV co-infected and 100 individuals were mono-HBV infection. Serum ALT and AST, HBsAg, HBeAg, anti-HBe, HBV DNA and anti-HCV IgG, HCV RNA were measured. The results showed that there was no significant difference in ALT and AST levels between the two groups (P=0.097, P=0.184); The positive rate of HBV DNA in the co-infection group was lower (P=0.004) compared with mono-HBV infection, and the HBsAg level and HBV DNA load in co-infection group were lower than those of mono-HBV infection (P=0.020, P=0.031); there was a positive correlation between HBV DNA and HBsAg in mono-HBV infected individuals (r=0.752, P<0.001), but the correlation is weakened in coinfected individuals(r=0.387, P=0.042). The results of this study suggested HCV coinfection significantly impact HBV replication and HBsAg secretion, which may indicate that HCV coinfection interfere with HBV replication.