正清风痛宁缓释片联合双醋瑞因治疗膝骨性关节炎的疗效观察

目的探讨正清风痛宁缓释片联合双醋瑞因胶囊治疗膝骨性关节炎的临床疗效。方法选取2017年6月—2018年5月三门峡市中心医院收治的92例膝骨性关节炎患者作为研究对象,将患者按照随机数字表法分为对照组和治疗组,每组各46例。对照组患者口服双醋瑞因胶囊,50 mg/次,2次/d。治疗组在对照组的基础上口服正清风痛宁缓释片,120 mg/次,2次/d。两组均连续治疗8周。观察两组患者的临床疗效,比较两组治疗前后的Lysholm评分、视觉模拟评分法(VAS)评分和关节活动度量表(ROM)评分。结果治疗后,治疗组的总有效率为89.13%,显著高于对照组的71.74%,两组比较差异具有统计学意义(P0.05)。治疗后,两组Lysholm评分和ROM评分均显著升高,VAS评分显著降低,同组治疗前后比较差异具有统计学意义(P0.05);治疗后,治疗组的Lysholm评分、ROM评分均明显高于对照组,VAS评分低于对照组,两组比较差异具有统计学意义(P0.05)。结论正清风痛宁缓释片联合双醋瑞因胶囊治疗膝骨性关节炎的疗效确切,能减轻疼痛,改善关节功能,具有一定的临床推广应用价值。

Clinical observation of Zhengqing Fengtongning Sustained Release Tablets combined with diacerein in treatment of knee osteoarthritis

Objective To investigate the clinical efficacy of Zhengqing Fengtongning Sustained Release Tablets combined with Diacerein Capsules in treatment of knee osteoarthritis. Methods Patients (92 cases) with knee osteoarthritis in Sanmenxia Central Hospital from June 2017 to May 2018 were randomly divided into control and treatment groups, and each group had 46 cases. Patients in the control group were po administered with Diacerein Capsules, 50 mg/time, twice daily. Patients in the treatment group were po administered with Zhengqing Fengtongning Sustained Release Tablets on the basis of the control group, 120 mg/time, twice daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical efficacy was evaluated, and the Lysholm scores, VAS scores, and ROM scores in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the treatment group was 89.13%, which was significantly higher than 71.74% in the control group, and there were differences between two groups (P<0.05). After treatment, Lysholm scores and ROM scores in two groups were significantly increased, but VAS score in two groups were significantly decreased, and the difference was statistically significant in the same group (P<0.05). After treatment, Lysholm scores and ROM scores in the treatment group were significantly higher than those in the control group, but VAS score were significantly lower than those in the control group, with significant difference between two groups (P<0.05). Conclusion Zhengqing Fengtongning Sustained Release Tablets combined with Diacerein Capsules has curative effect in treatment of knee osteoarthritis, can relieve pain, and improve the joint function, which has a certain clinical application value.