| 伸筋草生物碱对佐剂性关节炎大鼠的抗炎作用及机制研究 |
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| 引用本文： | 刘静,年华,徐熠,吴铁军,孙祎纯,邵燕婷,黄瑾. 伸筋草生物碱对佐剂性关节炎大鼠的抗炎作用及机制研究[J]. 现代药物与临床, 2019, 42(5): 869-872 |
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| 作者姓名： | 刘静 年华 徐熠 吴铁军 孙祎纯 邵燕婷 黄瑾 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院 药剂科, 上海 200437,上海中医药大学附属岳阳中西医结合医院 药剂科, 上海 200437,上海中医药大学附属岳阳中西医结合医院 药剂科, 上海 200437,上海中医药大学附属岳阳中西医结合医院 药剂科, 上海 200437,上海中医药大学附属岳阳中西医结合医院 药剂科, 上海 200437,上海中医药大学附属岳阳中西医结合医院 药剂科, 上海 200437,上海中医药大学附属岳阳中西医结合医院 药剂科, 上海 200437 |
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| 基金项目： | 上海市教委预算内项目（2015YSN46）；岳阳中西医结合医院院级基金（2018YJ06） |
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| 摘 要： | 目的 探讨伸筋草生物碱对完全弗氏佐剂（CFA）诱导大鼠关节炎的治疗作用及机制。方法 健康SD大鼠48只，随机分为6组，每组8只，即对照组、模型组、依托考昔片（阳性药，1 mg/kg）组及伸筋草生物碱低、中、高剂量（30、60、120 mg/kg）组，除对照组外，其余40只大鼠sc 0.1 mL CFA造模，致炎15 d后，连续ig给药30 d。测定大鼠足趾肿胀率、HE染色后观察造模测踝关节滑膜病理改变；致炎45 d，ELISA法测定血清中白介素-1β（IL-1β）、肿瘤坏死因子-α（TNF-α）水平。结果 与模型组比较，依托考昔片及伸筋草生物碱低、中、高剂量组足趾肿胀率均显著下降（P<0.05、0.01）；中、高剂量伸筋草生物碱明显改善滑膜细胞、巨噬细胞、纤维细胞增生与炎症细胞浸润；与模型组比较，依托考昔片及伸筋草生物碱高剂量组大鼠血清TNF-α水平显著下降（P<0.05），依托考昔片及伸筋草生物碱各剂量组IL-1β水平均显著降低（P<0.01）。结论 伸筋草生物碱显著抑制CFA诱导关节炎大鼠关节肿胀，改善大鼠踝关节滑膜病变，其作用机制可能与降低体内IL-1β、TNF-α水平有关。
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| 关 键 词： | 伸筋草生物碱 类风湿关节炎 白介素-1β(IL-1β) 肿瘤坏死因子-α(TNF-α) |
| 收稿时间： | 2018-08-09 |
Anti-inflammatory effect and mechanism of shenjincaoalkaloids on adjuvant arthritis rats |
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| LIU Jing,NIAN Hu,XU Yi,WU Tiejun,SUN Yichun,SHAO Yanting and HUANG Jin. Anti-inflammatory effect and mechanism of shenjincaoalkaloids on adjuvant arthritis rats[J]. Drugs & Clinic, 2019, 42(5): 869-872 |
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| Authors: | LIU Jing NIAN Hu XU Yi WU Tiejun SUN Yichun SHAO Yanting HUANG Jin |
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| Affiliation: | Dept. of Pharmacy, the Affiliated Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China,Dept. of Pharmacy, the Affiliated Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China,Dept. of Pharmacy, the Affiliated Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China,Dept. of Pharmacy, the Affiliated Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China,Dept. of Pharmacy, the Affiliated Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China,Dept. of Pharmacy, the Affiliated Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China and Dept. of Pharmacy, the Affiliated Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of TCM, Shanghai 200437, China |
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