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| 共聚焦显微镜在真菌性角膜炎诊治中的临床应用 | |
| 引用本文： | 蓝倩倩,陈琦,陈丽妃,沈朝兰,黄慧,曾思明.共聚焦显微镜在真菌性角膜炎诊治中的临床应用[J].国际眼科杂志,2019,19(3):523-526. |
| 作者姓名： | 蓝倩倩 陈琦 陈丽妃 沈朝兰 黄慧 曾思明 |
| 作者单位： | 中国广西壮族自治区南宁市,广西壮族自治区人民医院眼科,中国广西壮族自治区南宁市,广西壮族自治区人民医院眼科,中国广西壮族自治区南宁市,广西壮族自治区人民医院眼科,中国广西壮族自治区南宁市,广西壮族自治区人民医院眼科,中国广西壮族自治区南宁市,广西壮族自治区人民医院眼科,中国广西壮族自治区南宁市,广西壮族自治区人民医院眼科 |
| 基金项目： | 广西壮族自治区卫健委自筹经费科研项目(No.Z2016623) |
| 摘 要： | 目的：评价共聚焦显微镜联合角膜刮片在真菌性角膜炎中的临床应用。 方法：对我院临床诊断为真菌性角膜炎的患者56例56眼行共聚焦显微镜检查和角膜刮片检查，包括涂片后显微镜下检查和真菌培养，并进行药物或联合手术治疗，统计诊断的阳性率和治疗预后。 结果：入院时共聚焦显微镜诊断阳性率为91%，角膜刮片病原学检测诊断阳性率为54%，共聚焦显微镜和角膜刮片联合诊断阳性率为95%。治疗后，单纯药物治疗达到临床治愈者44眼(79%)，单纯药物治疗无法控制感染需要进行手术治疗者12眼(21%)。 结论：共聚焦显微镜具有非侵入性、快速、重复性好等特点，联合角膜刮片实验室检查可以提高真菌性角膜炎的诊断阳性率，更好地指导治疗。 |
| 关 键 词： | 共聚焦显微镜 角膜刮片 真菌性角膜炎 |
| 收稿时间： | 2018/11/17 0:00:00 |
| 修稿时间： | 2019/1/18 0:00:00 |
Clinical application of confocal microscopy in the diagnosis and treatment of fungal keratitis |
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| Qian-Qian Lan,Qi Chen,Li-Fei Chen,Chao-Lan Shen,Hui Huang and Si-Ming Zeng.Clinical application of confocal microscopy in the diagnosis and treatment of fungal keratitis[J].International Journal of Ophthalmology,2019,19(3):523-526. | |
| Authors: | Qian-Qian Lan Qi Chen Li-Fei Chen Chao-Lan Shen Hui Huang and Si-Ming Zeng |
| Institution: | Department of Ophthalmology, the People''s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,Guangxi Zhuang Autonomous Region, China,Department of Ophthalmology, the People''s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,Guangxi Zhuang Autonomous Region, China,Department of Ophthalmology, the People''s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,Guangxi Zhuang Autonomous Region, China,Department of Ophthalmology, the People''s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,Guangxi Zhuang Autonomous Region, China,Department of Ophthalmology, the People''s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,Guangxi Zhuang Autonomous Region, China and Department of Ophthalmology, the People''s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021,Guangxi Zhuang Autonomous Region, China |
| Abstract: | AIM:To assess the clinical application of confocal microscopy combined with corneal scraping in the diagnosis and treatment of fungal keratitis. METHODS: Totally 56 eyes of 56 patients with fungal keratitis from our hospital were included. All patients underwent confocal microscopy and cornea scraping for smear microscopy and fungal culture. The diagnostic yield was analyzed. RESULTS: The positive diagnostic rates of confocal microscopy and cornea scraping were 91% and 54% respectively,whereas in combination the positive diagnostic rate increased to 95%. 44 eyes(79%)were clinically cured with drugs alone while 12 eyes(21%)also required surgery. CONCLUSION: Confocal microscopy examination is non-invasive, with rapid detection and strong repeatability. When combined with corneal scraping it can be used to improve diagnostic yield and guide clinical therapy. |
| Keywords: | confocal microscopy corneal scraping fungal keratitis |
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