药用狗牙花枝叶的生物碱类成分研究

目的研究药用狗牙花Ervatamia officinalis枝叶的化学成分。方法采用硅胶、ODS、Sephadex LH-20、HPLC等色谱方法进行分离纯化,并根据化合物的理化性质及波谱学数据鉴定其化学结构。结果从药用狗牙花枝叶的总生物碱部位中分离得到14个生物碱类化合物,分别鉴定为7S-coronaridine hydroxyindolenine(1)、7S-voacangine hydroxyindolenine(2)、coronaridine(3)、19S-heyneanine(4)、voacangine(5)、tabernaemontanine(6)、dregamine(7)、3-(2-oxopropyl) coronaridine(8)、3-oxovoacangine(9)、voastrictine(10)、16R,19E-isositsirikine(11)、16R,19Z-isositsirikine(12)、16R,19E-isositsirikineN4-oxide(13)、geissoschizol(14)。结论化合物8～14为首次从该植物中分离得到。

Studies on alkaloids from twigs and leaves of Ervatamia officinalis

Objective To study the chemical constituents in the twigs and leaves of Ervatamia officinalis. Methods The chemical constituents were isolated from the total alkaloids of the twigs and leaves of Ervatamia officinalis by using silica gel, ODS, Sephadex LH-20, and HPLC. The chemical structures of the compounds were identified based on their physical and chemical properties and spectroscopic methods. Results Fourteen alkaloids were isolated and identified as 7S-coronaridine hydroxyindolenine (1), 7S-voacangine hydroxyindolenine (2), coronaridine (3), 19S-heyneanine (4), voacangine (5), tabernaemontanine (6), dregamine (7), 3-(2-oxopropyl) coronaridine (8), 3-oxovoacangine (9), voastrictine (10), 16R,19E-isositsirikine (11), 16R,19Z-isositsirikine (12), 16R,19E-isositsirikine N₄-oxide (13), and geissoschizol (14). Conclusion Compounds 8-14 are obtained from this plant for the first time.