八珍益母丸联合去氧孕烯炔雌醇治疗人工流产术后月经不调的临床研究

目的探讨八珍益母丸联合去氧孕烯炔雌醇片治疗人工流产术后月经不调的临床疗效。方法选取2015年4月—2018年4月在天津市中心妇产科医院诊治的人工流产术后月经不调患者106例,根据门诊号分为对照组(53例)和治疗组(53例)。对照组患者从月经周期的第1天开始每天同一时间口服去氧孕烯炔雌醇片,1片/次,1次/d,连续服用21 d,随后停药7 d;治疗组在对照组基础上口服八珍益母丸,6 g/次,2次/d。两组均治疗4周。观察两组患者临床疗效,同时比较治疗前后两组患者临床症状积分、性激素水平和月经周期天数。结果治疗后,对照组和治疗组临床总有效率分别为81.13%和96.23%,两组比较差异具有统计学意义(P0.05)。治疗后,两组临床症状积分均显著降低(P0.05),且治疗组临床症状积分明显低于对照组(P0.05)。治疗后,两组血清促卵泡素(FSH)和促黄体生成素(LH)水平明显升高(P0.05),雌二醇(E2)水平明显降低(P0.05),且治疗组FSH、LH和E2水平明显优于对照组(P0.05)。治疗后,两组患者月经周期天数均显著趋于正常化(P0.05),且治疗组在月经周期天数改善上显著优于对照组(P0.05)。结论八珍益母丸联合去氧孕烯炔雌醇片治疗人工流产术后月经不调可有效改善患者临床症状,有利于改善机体性激素水平和月经周期。

Clinical study on Bazhen Yimu Pills combined with desogestrel and ethinylestradiol in treatment of menstrual disorder after artificial abortion

Objective To investigate the clinical effect of Bazhen Yimu Pills combined with desogestrel and ethinylestradiol in treatment of menstrual disorder after artificial abortion. Methods Patients (106 cases) with menstrual disorder after artificial abortion in Tianjin Central Hospital of Gynecology Obstetrics from April 2015 to April 2018 were divided into control (53 cases) and treatment (53 cases) groups according to outpatient numbers. Patients in the control group were po administered with Desogestrel and Ethinylestradiol Tablets every day in the same time from the first day of the menstrual cycle, 1 tablet/time, once daily, continuous treatment for 21 d. Patients in the treatment group were po administered with Bazhen Yimu Pills on the basis of the control group, 6 g/time, twice daily. Patients in two groups were treated for 4 weeks. After treatment, the clinical efficacy was evaluated, and the clinical symptom scores, the sex hormone levels and the menstrual cycle days in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control and treatment groups was 81.13% and 96.23% respectively, and there were differences between two groups (P<0.05). After treatment, the clinical symptom scores in two groups were significantly decreased (P<0.05), and clinical symptom scores in the treatment group were significantly lower than those in the control group (P<0.05). After treatment, the FSH and LH levels in two groups were significantly increased (P<0.05), but the E2 levels were significantly decreased (P<0.05), and the FSH, LH, and E2 levels in the treatment group were significantly better than those in the control group (P<0.05). After treatment, the menstrual cycle days in two groups significantly tended to normalization (P<0.05), and the improvement of menstrual cycle days in the treatment group was significantly better than that in the control group (P<0.05). Conclusion Bazhen Yimu Pills combined with desogestrel and ethinylestradiol in treatment of menstrual disorder after artificial abortion can effectively improve the clinical symptoms, which is conducive to improving the sex hormones level and menstrual cycle.