| 电离辐射通过CXCL12/CXCR4信号轴调控肿瘤生物学行为的研究进展 |
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| 引用本文： | 谷庆,嵇建峰,郑晓. 电离辐射通过CXCL12/CXCR4信号轴调控肿瘤生物学行为的研究进展[J]. 中华放射医学与防护杂志, 2019, 39(12): 955-960 |
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| 作者姓名： | 谷庆 嵇建峰 郑晓 |
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| 作者单位： | 中国科学院肿瘤与基础医学研究所 中国科学院大学附属肿瘤医院 浙江省肿瘤医院放疗科, 杭州 321022,中国科学院肿瘤与基础医学研究所 中国科学院大学附属肿瘤医院 浙江省肿瘤医院放疗科, 杭州 321022,中国科学院肿瘤与基础医学研究所 中国科学院大学附属肿瘤医院 浙江省肿瘤医院放疗科, 杭州 321022 |
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| 基金项目： | 国家自然科学基金（81602672）；浙江省医药卫生科研项目（2019327308） |
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| 摘 要： | 电离辐射杀灭恶性肿瘤细胞的同时，可以影响恶性肿瘤的诸多生物学行为，包括肿瘤细胞的固有放射敏感性、侵袭转移、血管形成以及免疫反应等。趋化因子CXCL12及其受体CXCR4高表达于多种恶性肿瘤，参与了恶性肿瘤远处转移、血管形成、免疫调节、治疗抵抗等过程。近年来研究发现，CXCL12/CXCR4信号轴在电离辐射调控的恶性肿瘤生物学行为中发挥了关键作用。本文重点对电离辐射照射后恶性肿瘤发生的一系列生物学行为变化过程中，CXCL12/CXCR4信号轴发挥的具体作用进行综述及讨论。
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| 关 键 词： | CXCL12 CXCR4 转移 放射敏感性 免疫反应 |
| 收稿时间： | 2019-08-06 |
A CXCL12/CXCR4 axis in regulation of tumor behaviors by ionizing radiation |
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| Gu Qing,Ji Jianfeng and Zheng Xiao. A CXCL12/CXCR4 axis in regulation of tumor behaviors by ionizing radiation[J]. Chinese Journal of Radiological Medicine and Protection, 2019, 39(12): 955-960 |
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| Authors: | Gu Qing Ji Jianfeng Zheng Xiao |
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| Affiliation: | Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China,Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China and Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Hangzhou 310022, China |
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| Abstract: | In addition to induce cell death in tumor cells, ionizing radiation (IR) regulates many biological behaviors of malignant tumors, such as intrinsic radiosensitivity, invasion and metastasis, angiogenesis, as well as immune response of tumor cells. The C-X-C motif chemokine ligand 12 (CXCL12) and its receptor CXCR4 are highly expressed in a variety of malignant tumors, and are involved in the process of remote metastasis, blood vessel formation, immune regulation, and therapeutic resistance of malignant tumors. Recent studies have found that the CXCL12/CXCR4 signal axis plays critical roles in the IR-regulated biological behavior of malignant tumors. This paper reviews the roles of CXCL12/CXCR4 signal axis in the biological behavior changes of irradiated malignant tumors. |
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| Keywords: | CXCL12 CXCR4 Metastasis Radiosensitivity Immune reaction |
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