| 白首乌C21甾体苷抗肿瘤研究进展 |
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| 引用本文： | 邹锦鹏,冉聪,刘洋,游桂香,侯凯,吴卫. 白首乌C21甾体苷抗肿瘤研究进展[J]. 中草药, 2019, 50(3): 785-792 |
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| 作者姓名： | 邹锦鹏 冉聪 刘洋 游桂香 侯凯 吴卫 |
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| 作者单位： | 四川农业大学农学院, 四川 成都 611130,四川农业大学农学院, 四川 成都 611130,四川农业大学农学院, 四川 成都 611130,四川农业大学农学院, 四川 成都 611130,四川农业大学农学院, 四川 成都 611130,四川农业大学农学院, 四川 成都 611130 |
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| 基金项目： | 全国第四次中药资源普查（2018pc02） |
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| 摘 要： | 白首乌是一种补肾益肝、摄生防老的名贵中药,具有防癌、抗癌的药理作用。C_(21)甾体类化合物被认为是白首乌主要抗癌活性成分之一。对白首乌C_(21)甾体与糖基的主要类型、C_(21)甾体苷抗肿瘤的主要作用机制、对不同肿瘤的作用效果和影响因素、C_(21)甾体苷的毒理学等研究现状进行综述,为白首乌C_(21)甾体苷类抗癌药物的研究提供参考。
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| 关 键 词： | 白首乌 C21甾体苷 抗肿瘤 作用机制 毒理学 |
| 收稿时间： | 2018-12-03 |
Research progress on antitumor activities of C21 steroidal glycosides of Cynanchi Bungei Radix |
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| ZOU Jin-peng,RAN Cong,LIU Yang,YOU Gui-xiang,HOU Kai and WU Wei. Research progress on antitumor activities of C21 steroidal glycosides of Cynanchi Bungei Radix[J]. Chinese Traditional and Herbal Drugs, 2019, 50(3): 785-792 |
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| Authors: | ZOU Jin-peng RAN Cong LIU Yang YOU Gui-xiang HOU Kai WU Wei |
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| Affiliation: | College of Agriculture, Sichuan Agriculture University, Chengdu 611130, China,College of Agriculture, Sichuan Agriculture University, Chengdu 611130, China,College of Agriculture, Sichuan Agriculture University, Chengdu 611130, China,College of Agriculture, Sichuan Agriculture University, Chengdu 611130, China,College of Agriculture, Sichuan Agriculture University, Chengdu 611130, China and College of Agriculture, Sichuan Agriculture University, Chengdu 611130, China |
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| Abstract: | Cynanchi Bungei Radix is a precious Chinese meteria medica of tonifying kidney, benefiting liver, keeping fit, and preventing senility, which also has the pharmacological effect of cancer prevention and anticancer. C21 steroids glycosides are considered as one of its main anticancer active components. In this paper, the main types of C21 steroids and glycosyl groups, the main antitumor mechanism of C21 steroidal glycosides, the effect of C21 steroidal glycosides on different tumors and the influencing factors, and the toxicological research status of C21 steroidal glycosides were reviewed, which can provide references for the following research of C21 steroidal glycosides in Cynanchi Bungei Radix. |
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| Keywords: | Cynanchi Bungei Radix C21 steroidal glycosides antitumor action of mechanism toxicology |
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