CXCR7、E-cad及Vim在卵巢癌中的表达及其相关性研究

目的：分析CXCR7、E-cad及Vim在卵巢癌组织中的表达情况，CXCR7与E-cad、Vim表达的相关性，探讨其判断预后的意义。方法：采用免疫组织化学技术检测100例卵巢癌组织及其正常卵巢组织中CXCR7、E-cad及Vim的表达，分析CXCR7、E-cad及Vim的表达与患者临床病理参数的关系，CXCR7与E-cad、Vim相关性，以及CXCR7、E-cad及Vim不同表达量患者的生存率。结果：卵巢癌组织中CXCR7、E-cad及Vim高表达率分别为53.0%，38.0%和31.0%，正常卵巢组织分别为8.0%，55.0%和11.0%，差异均具有统计学意义（P<0.05）。CXCR7、E-cad及Vim表达情况与卵巢癌患者组织分化程度、FIGO分期及淋巴结转移相关（P<0.05）。CXCR7表达与E-cad表达呈负相关（r=-0.302，P=0.002），与Vim表达呈正相关（r=0.458，P<0.01）。CXCR7高表达患者中位生存期为37个月，短于低表达组的44.5个月（P=0.041）；E-cad高表达组中位生存期为48个月，长于低表达组的34个月（P=0.045）；Vim高表达组中位生存期为22.5个月，短于低表达组的44个月（P<0.01）；差异均有统计学意义。Cox多因素分析显示，卵巢癌分化程度、CXCR7表达及Vim表达情况是影响患者预后的独立危险因素（P<0.05）。结论：CXCR7与E-cad及Vim在卵巢癌组织中的表达存在相关性，联合检测卵巢癌组织中CXCR7、E-cad及Vim表达有助于评估预后。

Expression of CXCR7, E-cad and Vim in ovarian cancer and their correlation

Objective: To investigate the expression of CXCR7, E-cad and Vim in ovarian cancer tissues, correlate the expression of CXCR7 with E-cad and Vim, and explore the significance of prognosis. Methods: The expressions of CXCR7, E-cad and Vim in 100 cases of ovarian cancer and normal ovarian tissues were detected by immunohistochemistry. The relationships between the expressions of CXCR7, E-cad, Vim and the clinicopathological parameters of patients were analyzed. The correlation between CXCR7, E-cad, Vim and the survival rates of patients with different expressions of CXCR7, E-cad and Vim were also analyzed. Results: The high expression rates of CXCR7, E-cad and Vim in ovarian cancer tissues were 53.0%, 38.0% and 31.0%, respectively, and those in the normal ovarian tissues were 8.0%, 55.0% and 11.0%, respectively, the differences were statistically significant (P<0.05).The expression of CXCR7, E-cad and Vim was correlated with histological differentiation, FIGO stage and lymph node metastasis (P<0.05). The expression of CXCR7 was negatively correlated with E-cad (r=-0.302, P=0.002) and positively correlated with Vim (r=0.458, P<0.01). The median survival time of patients with high expression of CXCR7 was 37 months, shorter than 44.5 months in the low expression group (P=0.041); the median survival time of patients with high expression of E-cad was 48 months, longer than 34 months in the low expression group (P=0.045); the median survival time of patients with the high expression of Vim was 22.5 months, shorter than 44 months in the low expression group (P<0.01). The difference was statistically significant. Cox multivariate analysis showed that differentiation of ovarian cancer, CXCR7 expression and Vim expression were independent risk factors for prognosis (P<0.05). Conclusion: The expression of CXCR7, E-cad and Vim in ovarian cancer tissues were correlated with each other. Combined the detection of them in ovarian cancer can help to assess the prognosis.