脂肪因子Omentin-1、脂联素与中老年女性骨密度相关性研究

目的观察脂肪因子Omentin-1、脂联素与中老年女性骨密度之间的相关性。方法选取2017年3月至2018年4月在佛山市中医院就诊的338名女性,按照绝经状态分为围绝经期/绝经期组(n=194)和绝经后组(n=124)。将参研人员年龄、体质量指数(bone mass index,BMI)、腰围、吸烟状况、身体活动、脂联素、Omentin-1和激素进行多变量调整(ANCOVA),用于研究其脂肪因子和骨密度(bone mineral density,BMD)之间的潜在关系。结果与绝经后女性的腰椎BMD (0. 69±0. 08)g/cm~2]相比,围绝经期女性的腰椎BMD(0. 89±0. 09) g/cm~2]更高;在围绝经期/绝经期组女性中,脂联素和Omentin-1均与腰椎BMD无显著相关性(P0. 05);在绝经后组女性中,脂联素与腰椎BMD无相关性(P 0. 05);而在绝经后组女性中,Omentin-1与腰椎BMD呈显著负相关(P0. 05)。结论绝经后女性的Omentin-1与腰椎BMD呈负相关。

Correlation between adipokines Omentin-1, adiponectin and bone mineral density in middle-aged women

Objective To observe the correlation between adipokines Omentin-1, adiponectin and bone mineral density in middle-aged women. Method 338 women who were admitted to our hospital from March 2017 to April 2018 were selected. According to the menopausal status, the menopausal/menopausal group (n=194) and the postmenopausal group (n=124) were divided. Multivariable-adjusted ANCOVA including age, BMI, waist circumference, smoking status, physical activity, adiponectin or Omentin-1 and hormone use was used to investigate potential relationships between the adipokines and BMD. Results Peri-/premenopausal women had higher BMD of lumbar vertebrae (0.89±0.09g/cm2), compared to postmenopausal women (0.69±0.08g/cm2) (P<0.05). In peri-/premenopausal women neither adiponectin nor Omentin-1 was significantly associated with BMD of lumbar vertebrae(P>0.05). In postmenopausal women, adiponectin was not associated with BMD of lumbar vertebrae(P>0.05). In postmenopausal women, Omentin-1 was significantly negatively correlated with lumbar spine BMD (P<0.05). Conclusion Our study provides evidence for circulating Omentin-1 levels have an inverse correlation with BMD at the lumbar spine in postmenopausal women.