| 杜仲有效成分在帕金森病治疗中的药理作用研究进展 |
| |
| 引用本文： | 柴士伟,马静,庄朋伟,张艳军,郭虹.杜仲有效成分在帕金森病治疗中的药理作用研究进展[J].现代药物与临床,2019,42(5):1003-1009. |
| |
| 作者姓名： | 柴士伟 马静 庄朋伟 张艳军 郭虹 |
| |
| 作者单位： | 天津中医药大学第一附属医院, 天津 300193,天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 301617,天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 301617,天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 301617,天津中医药大学, 天津市现代中药重点实验室-省部共建国家重点实验室培育基地, 天津 301617 |
| |
| 基金项目： | 国家自然科学基金（81703827） |
| |
| 摘 要： | 帕金森病（Parkinson''s Disease，PD）是中老年人常见的神经系统变性疾病，其发病可受年龄、遗传和环境等因素影响，其主要病理机制为大脑黑质致密部多巴胺能神经元的病变缺失。保护多巴胺能神经元是行之有效的方法之一，脑内炎症反应、氧化应激等均可导致神经细胞的损伤。杜仲是常用补益中药，具有明确的神经保护作用，临床常用于PD的治疗，对近年杜仲及其有效成分在PD治疗中的药理作用研究进展做一综述，以期为杜仲在防治PD方面的开发应用提供一定线索。
|
| 关 键 词： | 杜仲 帕金森病 有效成分 |
| 收稿时间： | 2018/11/7 0:00:00 |
Research progress on pharmacological effects of effective components of Eucommia ulmoides on Parkinson's disease |
| |
| CHAI Shiwei,MA Jing,ZHUANG Pengwei,ZHANG Yanjun and GUO Hong.Research progress on pharmacological effects of effective components of Eucommia ulmoides on Parkinson's disease[J].Drugs & Clinic,2019,42(5):1003-1009. |
| |
| Authors: | CHAI Shiwei MA Jing ZHUANG Pengwei ZHANG Yanjun and GUO Hong |
| |
| Institution: | First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China,Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 301617, China,Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 301617, China,Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 301617, China and Tianjin University of Traditional Chinese Medicine, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin 301617, China |
| |
| Abstract: | Parkinson''s disease (PD) is a common neurodegenerative disease in the elderly people. Its pathogenesis can be affected by age, heredity and environment. Its main pathological mechanism is the loss of dopaminergic neurons in the substantia nigra. Protecting dopaminergic neurons is one of the effective methods. Inflammatory reaction and oxidative stress in brain can lead to damage of nerve cells. Eucommia ulmoides Oliv. is precious tonic herbs of traditional Chinese medicine with definite neuroprotective effect. It is commonly used in the treatment of PD in clinic. In this paper, the pharmacological effects and effective components in the treatment of PD in recent years are studied. This review will provide a clue for the development and application of Eucommia ulmoides Oliv. in the prevention and treatment of PD. |
| |
| Keywords: | Eucommia ulmoides Oliv Parkinson''s disease effective components |
|
| 点击此处可从《现代药物与临床》浏览原始摘要信息 |
| 点击此处可从《现代药物与临床》下载免费的PDF全文 |
|
