雪梨止咳糖浆联合孟鲁司特钠对小儿咳嗽变异性哮喘的疗效及安全性分析

目的 探讨雪梨止咳糖浆合孟鲁司特钠对小儿咳嗽变异性哮喘的疗效及安全性。方法 选择安阳市妇幼保健院2015年1月-2018年1月收治的81例咳嗽变异性哮喘患儿，根据随机数字表法分为观察组（39例）及对照组（42例），对照组患儿给予孟鲁司特钠，观察组在对照组基础上给予雪梨止咳糖浆，两组治疗疗程均为1个月。对比两组患儿的临床疗效，治疗前后的咳嗽、喘息、咳痰、哮鸣音、胸膈满闷积分，治疗前后的用力呼气流量（FEF）取25%、50%肺活量呼气流速占预计值的百分比及血清IgE水平，治疗期间两组的不良反应。结果 观察组总有效率为97.44%，明显高于对照组的80.95%，差异有统计学意义（P<0.05）。治疗后，两组的咳嗽、喘息、咳痰、哮鸣音、胸膈满闷评分均明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组明显低于对照组，差异有统计学意义（P<0.05）。治疗后，两组FEF25%、FEF50%均明显升高，IgE水平明显降低，同组治疗前后比较差异有统计学意义（P<0.05）；且观察组FEF25%、FEF50%明显高于对照组，而IgE水平明显低于对照组，组间差异有统计学意义（P<0.05）。两组的不良反应组间对比无统计学意义。结论 孟鲁司特钠联合雪梨止咳糖浆治疗小儿咳嗽变异性哮喘安全有效，值得临床推广应用。

Efficacy and safety of Xueli Zhike Tangjiang combined with monteluk sodium in children with cough variant asthma

Objective To investigate the efficacy and safety of Xueli Zhike Tangjiang combined with monteluk sodium in children with cough variant asthma.Methods 81 cases with cough variant asthma from Jan.2015 to Jan.2018 in our hospital were chosen and divided into the observation group (39 cases) and control group (42 cases),the control group were given monteluk sodium,the observation group were given Xueli Zhike Tangjiang on the base of control group,the clinical efficacy,the cough,wheezing,coughing,wheezing,and chest fullness before and after treatment,the FEF25%,FEF50% and IgE level in serum before and after treatment in two groups were compared,the adverse reaction of two groups were compared.Results The total effective rate was 97.44% in the observation group,which was significantly higher than 80.95 in the control group (P< 0.05).After treatment,the scores of cough,wheezing,expectoration,wheezing and chest diaphragm fullness in the two groups were significantly lower than those in the control group (P< 0.05),and those in the observation group were significantly lower than those in the control group (P< 0.05).After treatment,the levels of FEF 25% and FEF 50% in both groups were significantly increased,and IgE levels were significantly decreased.There was significant difference before and after treatment in the same group (P< 0.05).The levels of FEF25% and FEF50% in the observation group were significantly higher than those in the control group,while the levels of IgE were significantly lower than those in the control group (P< 0.05).There was no significant difference in adverse reactions between the two groups.Conclusion Xueli Zhike Tangjiang combined with montelukast sodium was safe and effective in treatment of cough variant asthma in children,which was worthy of clinical application.