| 阿比朵尔胶囊在健康人体内的药动学(英文) |
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| 引用本文： | 孙颖光,张淑慧,邱志宏,赫立恩,马杰. 阿比朵尔胶囊在健康人体内的药动学(英文)[J]. 中国新药与临床杂志, 2008, 27(3): 161-164 |
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| 作者姓名： | 孙颖光 张淑慧 邱志宏 赫立恩 马杰 |
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| 作者单位： | 河北省人民医院,药学部,河北,石家庄,050051 |
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| 摘 要： | 目的研究阿比朵尔胶囊在健康人体内的药动学。方法20名健康志愿者单剂量口服阿比朵尔胶囊200 mg后,血浆样品经液-液萃取后,以液相色谱紫外检测法测定血药浓度。用3P87统计软件进行数据处理。结果结果符合一级消除药动学的二室模型,阿比朵尔胶囊的主要药动学参数分别为:c_(max)一(418±s 241)μg·L~(-1),t_(max)(1.3±1.2)h,t_(1/2α)(1.9±2.3)h,t_(1/2β)(14±5)h,AUC_(0～t)(2633±1071)μg·h·L~(-1),Vc/F(0.7±0.6)L,CL(0.08±0.03)L·h~(-1)。结论阿比朵尔胶囊在人体内药动学过程符合二室开放模型,本试验可为临床用药提供药动学参数。
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| 关 键 词： | 阿比朵尔 药动学 色谱法 高压液相 |
| 文章编号： | 1007-7669(2008)03-0161-04 |
| 修稿时间： | 2007-10-19 |
Pharmacokinetics of arbidol capsule in Chinese healthy volunteers |
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| SUN Ying-guang,ZHANG Shu-hui,QIU Zhi-hong,HE Li-en,MA Jie. Pharmacokinetics of arbidol capsule in Chinese healthy volunteers[J]. Chinese Journal of New Drugs and Clinical Remedies, 2008, 27(3): 161-164 |
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| Authors: | SUN Ying-guang ZHANG Shu-hui QIU Zhi-hong HE Li-en MA Jie |
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| Abstract: | AIM To study the pharmacokinetics of arbidol capsule in Chinese healthy volunteers.METHODS A single oral dose of arbidol capsule 200 mg was given to 20 healthy volunteers respectively.Plasma samples were prepared based on a simple liquid-liquid extraction.The extracted samples were analyzed by HPLC equipped with UV detection.Pharmacokinetic parameters were calculated by 3P87 software. RESULTS The main pharmacokinetic parameters of arbidol were as follows:c(max)(418±s 241)μg·L-1,t(max)(1.3±1.2)h,t(1/2α)(1.9±2.3)h,t1/2β(14±5),hAU0-t(2 633±1 071)μg·L-1,Vc/F(0.7±0.6)L,CL(0.08±0.03)L·h-1,CONLUSION The pharmacokinetics of arbidol capsule in human body accord with two-compartmetn open model.The study will offer the pharmacokinetic parameters for the clinical application of arbidol. |
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| Keywords: | arbidol pharmacokinetics chromatography,high pressure liquid |
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