Ki-67在GCB及non-GCB弥漫性大B细胞淋巴瘤中的表达及意义 |
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引用本文: | 宋恩霖,熊小亮,艾有生,刘繁荣,朱静,刘勇. Ki-67在GCB及non-GCB弥漫性大B细胞淋巴瘤中的表达及意义[J]. 江西医药, 2011, 46(2): 111-114 |
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作者姓名: | 宋恩霖 熊小亮 艾有生 刘繁荣 朱静 刘勇 |
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作者单位: | 1. 南昌大学医学院,南昌,330006 2. 江西省人民医院 |
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基金项目: | 江西省卫生厅科研基金资助 |
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摘 要: | 目的探讨Ki-67在GCB及non-GCB型弥漫性大B细胞淋巴瘤中的表达及意义。方法收集60例DLBCL及19例淋巴结反应性增生组织,并制作其组织芯片,采用免疫组化观测CD1O、bcl-6、MUM1蛋白的表达对DLBCL进行生发中心样B细胞(germinal center B cell-like,GCB)和非生发中心样B细胞(non-GCB)免疫表型分类,同时检测Ki-67蛋白的表达。结果 (1)60例DLBCL中CD1O、bcl-6、MUM1蛋白的阳性表达率分别为33.3%、45%、63.3%,GCB类型29例(48.3%),non-GCB类型31例(51.7%)。(2)Ki-67蛋白在淋巴结反应性增生(不包括生发中心)阳性率明显低于DLBCL(P〈0.05)。(3)Ki-67蛋白的表达在DLBCL中GCB及non-GCB亚型中有显著性差异(P〈0.05)。结论 Ki-67的表达可能与DLBCL免疫学分型有关,在non-GCB中,Ki-67高表达。
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关 键 词: | Ki-67 弥漫性大B细胞淋巴瘤 组织芯片 |
Expression and significance of Ki - 67 in germinal centre and non-germinal centre B-like diffuse large B-cell lymphomas |
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Affiliation: | Song Enling,Xiong Xiaoliang,Ai Yousheng,et al.Department of pathology,Nanchang university medical school,Nanchang,30006,China |
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Abstract: | Objective To investigate the expression and significance of Ki-67 in germinal centre B-cell like(GCB)and non-germinal centre B-cell like(non-GCB) diffuse large B-cell lymphomas(DLBCL).Methods A tissue chip cotaining 60 cases of DLBCL and 19 cases of reactive hyperplasia of lymph nodes was constructed,using CD10,BCL-6,MUM1,the cases of DLBCL were subtyped molecuiary into GCB and non-GCB groups and the expression of Ki-67 protein were studied.Results(1)60 cases in DLBCL BCL-6,CD10,MUM1 protein positive expression rate were 33.3%,45%,63.3% respectively,GCB type 29 patients(48.3%),non-GCB type 31 cases(51.7%).(2) Ki-67 protein in lymph node reactive hyperplasia(not including germinal centers) were significantly lower than DLBCL(P0.05).(3) Ki-67 protein expression in DLBCL in GCB and non-GCB subtypes were significantly different(P0.05).Conclusion Ki-67 expression may be related with the immunosubgroups of DLBCL.in non-GCB,Ki-67 high expression. |
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Keywords: | Ki-67 |
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