茵栀黄联合微生态制剂用于新生儿高胆红素血症的临床研究

目的 探讨茵栀黄联合微生态制剂治疗新生儿高胆红素血症的疗效.方法 收集2010年5月至2012年8月华北石油管理局总医院儿科新生儿高胆红素血症患儿80例,采用随机数字表法将患儿随机分为两组各40例,对照组采用间隙蓝光照射,对胆红素上升快或水平高者给予纠酸、肝酶诱导剂、白蛋白静脉滴注等常规治疗方法.治疗组在对照组治疗基础上加用茵栀黄联合微生态制剂治疗.两组治疗前查血清总胆红素,治疗期间,应用经皮胆红素监测仪,监测每天胆红素变化,同时监测血清胆红素值下降至正常的时间.结果 治疗后治疗组日均胆红素下降值（53.07±17.80） μmol/L与对照组（30.56±13.43）μmol/L比较差异有统计学意义（P＜0.05）;治疗组胆红素降至正常时间（4.87±2.06）d与对照组（7.12±2.33）d比较,差异均有统计学意义（P＜0.05）;茵栀黄联合微生态制剂治疗组显效率75％ （30/40）明显高于对照组显效率35％ （14/40）,两组显效率比较差异有统计学意义（x2=5.89,P＜0.05）;茵栀黄联合微生态制剂治疗组总有效率92.5％ （37/40）,明显高于对照组总有效率75％ （30/40）,两组总有效率比较,差异有统计学意义（x2=4.50,P＜0.05）.结论 茵栀黄联合微生态制剂治疗新生儿高胆红素血症日均胆红素下降值、血清胆红素值下降至正常的时间均优于常规治疗.

Clinical study on Yinzhi-huang combined with probiotics in the treatment of neonatal hyperbilirubinemia

Objective To investigate the therapeutic efficacy of Yinzhi-huang combined with probiotics in the treatment of neonatal hyperbilirubinemia.Methods 80 neonates of hyperbilirubinemia were recruited into a treatment group （40 cases） and a control group （40 cases）.The control group was treated with the gap blue light irradiation,besides,patients with rapid increase or high level of bilirubin were additionally treated with acid-correcting agents,Liver enzyme inducer,and albumin infusion; while the treatment group was additionally treated with Yinzhi-huang and probiotics on the basis of the control group.The values of serum total bilirubin before the treatment Was determined in both groups.During treatment,the changes of daily bilirubin,were monitored with percutaneous bilirubin monitor,and the time for serum bilirubin values decreased to normal level was studied in both groups.Results The two groups showed no significant difference in examination of the serum bilirubin values before treatment（P〉0.05）.The daily bilirubin decreased value of treatment group（53.07± 17.80） μmol/L showed statistically significant compared with the control group（30.56± 13.43）μmol/L（P〈0.05）; the time for serum bilirubin values decreased to normal level in the treatment group （4.87± 2.06） d was significantly different compared with the control group （7.12± 2.33） d,（P〈 0.05）.The apparent effective rate in the treatment group 75% （30/40） was higher than that in the control group 35%（14/40）with statistical significance（x2=5.89,P〈0.05）.The total effective rate in the treatment group 92.5% （37/40）was higher than the control group 75% （30/40）with statistical significance （x2=4.50,P〈0.05）.Conclusion Yinzhi-huang combined with probiotics has better effects than conventional treatment in decreasing the daily bilirubin values,restoring normal serum bilirubin time of neonatal hyperbilirubinemia and it is worthy of clinical application.