三维适形放疗同步奈达铂化疗治疗食管癌的近期疗效观察

目的-观察奈达铂(NDP)同步三维适形放疗治疗中晚期食管癌的临床疗效和不良反应。方法43例经过病理组织学诊断为中晚期食管鳞状细胞癌的患者进行三维适形放疗，总剂量DT(60～66)Gy/(30～33)次，同期每周给予奈达铂单药化疗，NDP 40mg/m²。结果 41例患者可评价疗效和不良反应。随访至放疗后3月，9例CR，20例PR，有效率为70. 7%。主要剂量限制性毒性为骨髓抑制和放射性食管炎。结论 三维适形放射治疗同步奈达铂化疗能明显提高食管癌的近期疗效，且不良反应可耐受。

Nedaplatin Combined with Synchronous Three-Dimensional Conformal Radiotherapy in Treatment of Esophageal Cancer

Objective To evaluate the efficacy and safety of nedaplatin (NDP) and combined with synchronous three-dimensional conformal radiotherapy in the treatment of esophageal cancer. Methods Three dimensional conformal radiotherapy was administered in 43 cases of advanced esophageal squamous cell carcinoma, with a total dose of (60～66)Gy/(30～33)Fx. Combination chemotherapy was NDP 40mg/m², weekly. Results Of 43 patients in this trial, the response and toxicity of 41 cases were available to be evaluated. The response rate was 70.7% after 3 months of follow up. The most common adverse events were myelosuppression and radiation esophagitis. Conclusion Three dimensional conformal radiotherapy was combined with nedaplatin can improve the lately effective rate of patients with esophageal carcinoma. The toxicities for the patients are tolerable．