经肝血管插管栓塞化疗对肝癌切除术患者预后的影响

目的:探讨经肝血管插管栓塞化疗对肝癌切除术后患者预后的影响。方法:将219例肝癌切除术后患者分为治疗组(经肝血管插管栓塞化疗)74例和对照组(未行肝血管插管栓塞化疗)145例,分析经肝血管插管栓塞化疗对肝癌切除术后患者预后的影响。结果:对残癌低危者,治疗组和对照组术后1、2、3、4年生存率分别为77.8%、60.4%、53.2%、53.2%和72.9%、65.1%、56.2%、43.5%,生存率差异无显著性(P=0.7667);对残癌高危者,治疗组和对照组术后1、2、3、4年生存率分别为71.6%、58.7%、47.1%、43.1%和56.4%、49.5%、37.4%、37.4%,生存率差异无显著性(P=0.0029)。Cox模型分析结果表明有无残癌是影响患者预后的主要危险因素。结论:肝癌切除术后经肝血管插管栓塞化疗能延长不能根治性切除患者的生存期。

The Influence of Hepatiec Artery Chemotherapy and Embolization on Prognosis of Patients with Hepatocellular Carcinoma underwent Resection

Objective:To explore the effect of the hepatic artery ligation and cannulation on the prognosis of patients with hepatocellular carcinoma(HCC)underwent surgical resection.Methods:The Clinical data of 219 patients with HCC after resecton were analysed,all patients were divided two groups,the treatment group(74 patients)and the contrd group(145 patients).The treatment group were underwent chemotherapy and embolization through hepatic artery,while the control group were withalt.The influence of chemotherapy and embolization on prognosis were analyzed.Results:In low-risk residue cancer patients,when comparison was made between control and treatment group,the 1,2,3,4 year's survival rate were 77.8%,60.4%,53.2%,53.2% and 72.9%,65.1%,56.2%,43.5% respectively(P=0.7667).In high-risk residue cancer patients,when comparison was made between control and treatment group,the 1,2,3,4 year's survival rate were 71.6%,58.7%,47.1%,43.1% and 56.4%,49.5%,37.4%,37.4%,respectively(P=0.0029).Conclusion:Local chemotherapy through hepatic artery was an effective to prolong survival time for patients with high-risk recurrent potential HCC after surgical resection.