脐带间充质干细胞对C57BL/6小鼠Lewis肺癌生长及转移的影响

目的 利用Lewis肺癌动物模型，探讨脐带来源的MSC对恶性肿瘤生长及其转移的影响。方法 将16只C57BL/6小鼠分别建立Lewis肺癌模型，随机分为对照组（NS组）和MSC组，每组8只，MSC组分别于接瘤后第7、12、17天时，尾静脉注射给予脐带MSC（1×106/只），在第21天时处死全部荷瘤小鼠，观察瘤体生长情况及肺转移情况。结果 NS组和MSC榈钠骄鲋胤直鹞?.5875±1.04g、 4.155±1.13g，两组相比没有显著性差异（P>0.05）。NS组和MSC组的平均肺转移数分别为3.75±1.39个、1.13±1.13个，抑制转移率为70.0%，两组相比具有显著性差异（P<0.001）。结论 脐带来源的MSC对C57BL/6小鼠Lewis肺癌本身的生长无影响，但能够明显抑制肿瘤的转移。

Effects of umbilical cord-derived mesenchymal stem cells on growth and metastasis of Lewis lung carcinoma in C57BL/6 mice

Objective To study the effects of umbilical cord-derived mesenchymal stem cells (MSCs) on the growth and metastasis of lung cancer using Lewis lung carcinoma animal models. Methods Animal models of Lewis lung carcinoma were established in 16 C57BL/6 mice and were randomly divided into normal saline (NS) group and MSC group (n=8). Mice in the MSC group were injected with 1×106 MSCs via the tail vein at day 7, 12, and 17. All mice were sacrificed to observe the lung metastases and the tumor size at day 21. Results The average tumor weight was (4.587 5±1.04) g in the NS group and (4.155±1.13) g in the MSC group (P=0.59). The average number of lung metastasis nodules was 3.75±1.39 in the NS group and 1.13±1.13 in the MSC group (P<0.01), showing an inhibitory rate of 70%. Conclusion Umbilical cord-derived MSCs have no effects on the growth of Lewis lung carcinoma in mice, but they can inhibit tumor metastasis.