| 人参皂苷Rg3二元固体分散体的制备及体外特性研究 |
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| 引用本文： | 刘其媛,张振海,金鑫,于兆慧,贾晓斌.人参皂苷Rg3二元固体分散体的制备及体外特性研究[J].中国中药杂志,2013,38(24):4298-4302. |
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| 作者姓名： | 刘其媛 张振海 金鑫 于兆慧 贾晓斌 |
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| 作者单位： | 南京中医药大学, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;南京中医药大学, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;南京中医药大学, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028;江苏省中医药研究院 国家中医药管理局中药释药系统重点研究室, 江苏 南京 210028 |
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| 基金项目： | 江苏省中医药领军人才项目（2006）；国家中医药管理局中药口服制剂释药系统重点研究室开放基金课题（2011NDDCM01002） |
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| 摘 要： | 该文以低相对分子质量壳聚糖和泊洛沙姆188为联合载体，采用溶剂法制备人参皂苷Rg3固体分散体，进行体外溶出试验，并通过差示扫描量热法（DSC）、扫描电镜（SEM）和X-射线衍射法（X-RD）进行物相分析。结果表明，低相对分子质量壳聚糖和泊洛沙姆188按2：1制备的人参皂苷Rg3固体分散体60 min药物的体外累积溶出率达到90%以上，且药物以非晶状态分散于载体中。因此，以低相对分子质量壳聚糖和泊洛沙姆188为联合载体制备的人参皂苷Rg3固体分散体能够显著提高药物的溶出度，具有实际应用价值。
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| 关 键 词： | 人参皂苷Rg3 二元固体分散体 低相对分子质量壳聚糖 泊洛沙姆188 溶出度 |
| 收稿时间： | 2013/4/10 0:00:00 |
Study on preparation and in vitro characteristics of ginsenoside Rg3 binary solid dispersion |
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| LIU Qi-yuan,ZHANG Zhen-hai,JIN Xin,YU Zhao-hui and JIA Xiao-bin.Study on preparation and in vitro characteristics of ginsenoside Rg3 binary solid dispersion[J].China Journal of Chinese Materia Medica,2013,38(24):4298-4302. |
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| Authors: | LIU Qi-yuan ZHANG Zhen-hai JIN Xin YU Zhao-hui and JIA Xiao-bin |
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| Institution: | Nanjing University of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica under State Administration of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine of Jiangsu Province, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica under State Administration of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine of Jiangsu Province, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica under State Administration of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine of Jiangsu Province, Nanjing 210028, China;Nanjing University of Chinese Medicine, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica under State Administration of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine of Jiangsu Province, Nanjing 210028, China;Key Laboratory of New Drug Delivery System of Chinese Materia Medica under State Administration of Traditional Chinese Medicine, Academy of Traditional Chinese Medicine of Jiangsu Province, Nanjing 210028, China |
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| Abstract: | With low molecular weight chitosan and poloxamer 188 as the joint carriers, ginsenoside Rg3 solid dispersions were prepared by using the solvent evaporation method for an in vitro dissolution test. Subsequently, differential scanning calorimetry(DSC), scanning electron microscopy(SEM) and X-ray diffraction(X-RD) were adopted for a phase analysis. The results showed that the 60 min in vitro cumulative dissolution rate of ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 at the ratio of 2:1 exceeded 90%, and the drug was dispersed in carriers in an amorphous state. Therefore, ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 could help significantly improve the drug dissolution, with a practical application value. |
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| Keywords: | ginsenoside Rg3 binary solid dispersion low molecular weight chitosan poloxamer 188 dissolution |
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