| 鼻咽癌增量时间调节化疗加后程三维适形放射治疗的临床研究 |
| |
| 引用本文： | 李媛媛,曾英,何明媛,金风,吴伟莉,龙金华,龚修云,陈国炎,毕婷,李卓琳,贺前勇.鼻咽癌增量时间调节化疗加后程三维适形放射治疗的临床研究[J].中华放射医学与防护杂志,2013,33(6):630-634. |
| |
| 作者姓名： | 李媛媛 曾英 何明媛 金风 吴伟莉 龙金华 龚修云 陈国炎 毕婷 李卓琳 贺前勇 |
| |
| 作者单位： | 550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科;550004 贵阳, 贵州省肿瘤医院头颈肿瘤科 贵阳医学院附属医院头颈肿瘤科 |
| |
| 摘 要： | 目的 探讨顺铂+5-氟尿嘧啶/亚叶酸钙（DDP+5-FU/CF）增量时间调节化疗加后程三维适形放疗治疗鼻咽癌的疗效。方法 2006年3月至2007年10月收治60例鼻咽癌患者，按信封法随机分为两组：增量时间调节化疗加后程三维适形放疗（3D-CRT）组（时辰组）和常规放化疗组（常规组），每组30例。所有病例均先采用两周期诱导化疗后行单纯放疗。两组化疗方案及用药剂量相同，DDP总量100 mg/m2，5-FU 1 g/m2·d，连用3 d，14 d为1个周期，共2个周期。两组化疗后均用直线加速器给予鼻咽部相同的放疗剂量DT70 Gy/7周，2 Gy/次，5次/周。鼻咽部应用面颈联合野常规放疗DT 36 Gy/4周后，常规组缩野改为常规耳前野放疗DT 34 Gy/3~4周，时辰组改为后程三维适形放疗DT34 Gy/3~4周。结果 时辰组完全缓解率（CR）及有效率（CR+PR）分别为50%和100%，高于常规组的23.3%和93.3%，其中CR的差异有统计学意义（χ2 =4.593，P<0.05）。1、 3、 5年总生存率及无疾病生存率两组的差异无统计学意义。相对于常规组，时辰组化疗的骨髓及消化道不良反应减低（χ2=4.285、4.344，P<0.05）。结论 DDP+5-FU/CF增量时间调节化疗加后程三维适形放疗较常规放化疗能减轻骨髓及消化道的不良反应，提高鼻咽癌的完全缓解率，但未降低远期生存率。
|
| 关 键 词： | 鼻咽癌 增量时间调节化疗 后程三维适形放疗 |
| 收稿时间： | 4/8/2013 12:00:00 AM |
Incremental chrono-chemotherapy plus late course three-dimensional conformal radiotherapy and incremental conventional chemotherapy plus radiotherapy for nasopharyngeal carcinoma |
| |
| LI Yuan-yuan,ZENG Ying,HE Ming-yuan,JIN Feng,WU Wei-li,LONG Jin-hu,GONG Xiu-yun,CHEN Guo-yan,BI Ting,LI Zhuo-lin and HE Qian-yong.Incremental chrono-chemotherapy plus late course three-dimensional conformal radiotherapy and incremental conventional chemotherapy plus radiotherapy for nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2013,33(6):630-634. |
| |
| Authors: | LI Yuan-yuan ZENG Ying HE Ming-yuan JIN Feng WU Wei-li LONG Jin-hu GONG Xiu-yun CHEN Guo-yan BI Ting LI Zhuo-lin and HE Qian-yong |
| |
| Institution: | Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China;Department of Head and Neck Oncology, Guizhou Provincial Cancer Hospital, Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China |
| |
| Abstract: | |
| |
| Keywords: | Nasopharyngeal carcinoma Incremental chrono-chemotherapy Late course three-dimensional conformal radiotherapy |
|
| 点击此处可从《中华放射医学与防护杂志》浏览原始摘要信息 |
| 点击此处可从《中华放射医学与防护杂志》下载免费的PDF全文 |
|
