醋酸舍莫瑞林的免疫活性研究

目的　观察醋酸舍莫瑞林对免疫抑制模型小鼠免疫功能的调节作用。方法　通过给小鼠腹腔注射免疫抑制剂环磷酰胺 ,建立免疫功能低下模型 ,腹腔注射醋酸舍莫瑞林进行体内拮抗实验。测定胸腺指数、脾脏指数、巨噬细胞吞噬功能、T淋巴细胞的增殖指数、耳肿胀度、血清IL - 2的含量。结果　醋酸舍莫瑞林 ( 0 18,0 36mg/kg)能显著提高被环磷酰胺抑制的胸腺和脾脏重量 (P <0 0 1) ;使巨噬细胞吞噬功能明显增加 ,并能拮抗环磷酰胺对小鼠脾脏T淋巴细胞增殖、二硝基氯苯 (DNCB)诱导的迟发型超敏反应和IL - 2产生的免疫抑制作用。结论　醋酸舍莫瑞林能拮抗环磷酰胺所引发的免疫抑制作用

Study on immunocompetence of sermorelin acetate

Objective To research the adjustment of sermorelin acetate on immunization function of immunization inhibiting model of rats.Methods The mouse model of immunosuppression induced by cyclophosphamide,and sermorelin acetate was injected into mice abdominal cavity,antagonistic experiments were observed in vivo ,determining thymus gland index,the spleen index,phagocytosis of the phagocytes,proliferation index of T lymphocyte,ear swelling degree,content of IL-2 of serum. Results Sermorelin acetate(0 18,0 36?mg/kg)can clearly increase and odviously strengthen the thymus gland index and the spleen index;and clearly increase the phagocytosis of the phagocytes.Sermorelin acetate can antagonize inhibition of immunological function caused by cyclophosphamide,which can promote T lymphocyte proliferation,delayed-type hypersensitivity induced by dinitrochlorobenzene and production of IL-2 of the rat.Conclusion Sermorelin acetate can antagonize immunosuppressive response induced by cyclophosphamide.