静脉注射美托洛尔治疗不稳定型心绞痛临床疗效观察

目的观察静脉注射美托洛尔对不稳定型心绞痛(UAP)患者的疗效与安全性。方法选择18例严重且硝酸甘油疗效欠佳的UAP患者,静脉推注美托洛尔5~15mg后,继以25~100mg每日2次口服,观察心绞痛症状、心电图变化。结果(1)18例中14例UAP患者心绞痛发作静脉推注美托洛尔后(8.2±8.0)min时即缓解,8例用药后24h内心绞痛未再发作。用药前后24h相比,心绞痛发作次数减少、每次持续时间缩短(P<0.01)。(2)静注美托洛尔使12例患者异常ST段恢复,4例明显改善,2例无改善。(3)静脉使用美托洛尔后心率、血压下降。(4)出现4例窦性心动过缓,经处理后恢复。结论静脉注射美托洛尔后口服维持治疗UAP是安全、有效的。

The clinical efficacy and safety of intravenous injection of betaloc in the treatment of unstable angina pectoris

Objective To investigate the clinical efficacy and safety of intravenous injection of betaloc in patients with unstable angina pectoris (UAP).Methods 18 patients with UAP whose symptoms were serious and resistant to nitroglycerin were studied by injecting betaloc intravenously,firstly 5～15 mg,then 25～100 mg twice a day. The changes of symptoms of angina pectoris and electrocardiogram (ECG) were observed.Results (1) 14 of 18 patients with UAP relieved (8.2±8.0) minutes after they were intravenously injected with betaloc, and 8 patients had no onset 24 hours after administration. As compared with that before administration,the onset frequency of angina pectoris was decreased and the resistant time was significantly shortened after administration with betaloc (P<0.01).(2) Abnormal ST segments on ECG restored to normal position in 12 cases, obviously improved in 4 cases and have no change in 2 cases.(3) Heart rate (HR) and blood pressure (BP) were significantly lowered after 10 min of intravenous injection of betaloc.(4) Sinus bradycardia was present in 4 cases but recovered after immediate management.Conclusion The therapy of intravenous injection of betaloc is effective and safe for patients with UAP and for those with refractory unstable angina pectoris.