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| 硒化壳聚糖和亚硒酸钠抗K562细胞的实验研究 | |
| 引用本文： | 邓守恒,孙各琴,周有利,邓守平,陈崇宏.硒化壳聚糖和亚硒酸钠抗K562细胞的实验研究[J].海峡药学,2005,17(3):147-149. |
| 作者姓名： | 邓守恒 孙各琴 周有利 邓守平 陈崇宏 |
| 作者单位： | 1. 湖北郧阳医学院附属太和医院检验部,十堰,442000;湖北郧阳医学院基础医学院,十堰,442000;福建医科大学药学院,福州,350004 2. 湖北郧阳医学院基础医学院,十堰,442000 3. 湖北郧阳医学院附属太和医院检验部,十堰,442000 4. 湖北郧阳医学院堰桥医院,十堰,442000 5. 福建医科大学药学院,福州,350004 |
| 摘 要： | 应用MTT比色分析法比较研究有机硒化物-硒化壳聚糖和无机硒化物亚硒酸钠对白血病K562细胞的作用。结果表明：两种硒在体外实验浓度范围内均对K562细胞的增殖具有显著的抑制作用，并有剂量反应关系：硒化壳聚糖的抗白血病效应明显高于含同样硒量的亚硒酸钠，约为其3倍，有机硒比无机硒具有更高的抗白血病活性。 |
| 关 键 词： | 硒化壳聚糖 亚硒酸钠 K562细胞 抗白血病效应 |
| 文章编号： | 1006-3765(2005)03-0147-03 |
Experimental Study on K562 Cells of Organic Selenium Compound and Inorganic Selenium Compound |
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| DENG Shou-heng,SUN Ge-qing,Zhou You-li,DENG Shou-ping,Cheng Cong-hong.Experimental Study on K562 Cells of Organic Selenium Compound and Inorganic Selenium Compound[J].Strait Pharmaceutical Journal,2005,17(3):147-149. | |
| Authors: | DENG Shou-heng SUN Ge-qing Zhou You-li DENG Shou-ping Cheng Cong-hong |
| Abstract: | The anti leukemia effects of organic selenium compound and inorganic selenium compound-sodium selenite were studied in K562 cells in culture with MTT colorimetric assay. The data showed that both selenium significantly inhibited the proliferation of K562 cells in vitro. Compared with sodium selenite containing the same amount of Se, the organic selenium compound was more effective, its effect was about 3 times as high as that of sodium selenite. |
| Keywords: | Organic selenium compound Sodium selenite K562 |
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